introduction: bleomycin sulfate is a dna damaging agent used in cancer chemotherapy. the effect of this drug on various cell cycle stages might be different, thus inducing different modes of death (apoptotic or mitotic death). the aim of this investigation was to study the effects of bleomycin on human peripheral blood lymphocytes at various cell cycle stages by two different end points (induct...

Compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to possess the potential ability in preventing tumor development and suppressing cancer growth. However, the exact mechanism of its antitumorigenic effects is still not clear. The purpose of this project was to detect whether CK has an antican...

Wnt5a is a representative ligand that activates the b-catenin–independent pathway inWnt signaling. It was reported that the expression of Wnt5a in human gastric cancer is associated with aggressiveness and poor prognosis and that knockdown ofWnt5a reduces the ability of gastric cancer cells to metastasize in nudemice. Therefore, Wnt5a and its signaling pathway might be important targets for the...

Plasmid DNA/galactosylated poly-L-lysine(GalPLL) complex was used to transfer luciferase reporter gene in vitro into human hepatoma cells by a receptor-mediated endocytosis process. DNA was combined with galPLL via charge interaction (DNA:GalPLL:fusogenic peptide, 1:0.4:5, w/w/w) and the resulting complex was characterized by dynamic light scattering, gel retardation assay and zeta potential an...

objective(s):according to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. in the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. materials and methods:all synthesized derivatives were evaluated towards three hu...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

In this note, the concepts of (G1,G2)-open, (G1,G2)-closed, (G1,G2)-quotient and (G1,G2)-perfect mappings on arbitrary sets are introduced some theorems them established firstly. particular, results improve corresponding in [17]. Secondly, we give a partial answer to question posed by L. Liu [14]. Finally, properties G-topological groups, G-connectedness totally G-disconnectedness groups discus...

Lung cancer is the leading cause of mortality worldwide, and malignant melanomas are highly lethal owing to their elevated metastatic potential. Despite improvements in therapeutic approaches, treatments not completely effective. Thus, new drug candidates continuously sought. We synthesized mono- di-methoxylated cinnamic acid esters investigated antitumor A cell viability assay was performed id...

objective(s) two new adjuvants from natural animal lipids (g2) and bacterial polysaccharide extracts (pc) were previously prepared by our group and showed a reduction in tracheal responsiveness. the aim of this study was to evaluate the preventive effect of recently introduced natural products (g2 and pc) on the development of asthma. materials and methods asthma was induced using a standard me...