purpose: the aim of this study was to test the in vitro sensitivity of lymphocytes of patients with head and neck cancer against gamma irradiation and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy. patients and methods : peripheral blood of 101 patients with head and neck cancer was collected before the onset of radiotherapy, cultured...

Supplemental assays, such as recombinant immunoblot assays (RIBA), are used to confirm detection of antibodies to hepatitis C virus (HCV). However, due to their expense, they are not widely used in developing countries. The purpose of our study was to compare the results of second- and third-generation (G2 and G3, respectively) enzyme immunoassays (EIAs) and to resolve discordant results by usi...

objective(s): first, 10-bromodecanoic acid was covalently attached to all available surface primary amines of ppi g2 and g3 to increase their lipophilicity. in the subsequent step, ppis were conjugated to the alkylcarboxylate groups of alkylcarboxylate-ppi derivatives to increase the number of surface primary amines. physicochemical properties of modified ppis were determined. transfection expe...

Objective(s): First, 10-bromodecanoic acid was covalently attached to all available surface primary amines of PPI G2 and G3 to increase their lipophilicity. In the subsequent step, PPIs were conjugated to the alkylcarboxylate groups of alkylcarboxylate-PPI derivatives to increase the number of surface primary amines. Physicochemical properties of modified PPIs were determined. Transfection expe...

BACKGROUND: To achieve delivery of a drug to tumors, folic acid (FA) was used as a targeting ligand to change nanocarriers. Since the folate receptor has more expression in several tumor types such as breast cancer....

The selective activity of an antineoplastic drug is related to its ability promote cytotoxic action on tumor cells and preserve the integrity non-neoplastic cells. Beta-lapachone extracted from sawdust Ipe wood, a thick bark tree wood found in Brazilian Cerrado biome. This study aimed evaluate beta-lapachone endothelial cell line. EA.hy926 were seeded two groups, G1 G2, cultured exposed at conc...

PURPOSE The (131)I-tRRL small peptide probe has been identified in our previous study as a robust tumor molecular radiopharmaceutical that specifically binds to tumor-derived endothelial cells. In this study we developed a smaller structure cyclic tRRL (g2) radiolabeled with (99m)Tc as a novel and optimized peptide probe on tumor angiogenesis molecular imaging. METHODS Both tRRL (g2) and cont...

Increased yield of chromatid breaks, following in vitro G2-phase lymphocyte irradiation, can be a marker of individual radiosensitivity and cancer predisposing genes whose role is to respond to DNA damage. Mutations or polymorphisms of genes encoding DNA repair pathways may underlie the increased chromosomal radiosensitivity. However, genes that facilitate DNA damage recognition, using signal t...

Objective(s): Early diagnosis of cancer using noninvasive imaging techniques has been discussed in several recent studies. The present study aimed to assess the synergistic effects of iodixanol-conjugated polyethylene glycol (PEG)-citrate (anionic linear globular) dendrimer G2 on MCF-7 breast cancer cells and human embryonic kidney 293 (HEK293) cells. Materials and Methods: PEG-citrate de...

This study evaluated the effect of VêO® premium (2 or 4)g and ascorbic acid on pregnant ewes some minerals. Twenty Iraqi are aged 2-4 years in Fallujah, Al-Anbar Government regions from August 5th, 2019, to February 9th, 2020. The were divided randomly into four groups. It was fed naturally one diet, (G1) given 4 g, (G2) 2 (G3) 40 mg, (G4) treated as control group. Blood samples taken monthly v...