aim : the present study aimed to evaluate the prevalence of positive family history of these cancers in a large population-based sample of tehran province, capital of iran. background : upper gastrointestinal (ugi) cancers (gastric and esophagus cancer) constitute a major health problem worldwide. a family history of cancer can increase the risk for developing cancer and recognized as one of th...

abstract background: gastric cancer is a life threatening disease. recent studies have shown that rosa damascene possesses noticeable biological effects on the human body. this study, investigates the anticancer effect of rosa damascena on gastric cancer cell line mkn45. methods: microscopic studies and mtt assay were used to examine morphological alteration, and cell survival of the cancer cel...

Background and Objective: Host genetic factors such as cytokine gene polymorphisms as well as Helicobacter pylori (H. pylori) infection have been found to be associated with gastric cancer risk . Interleukin 1 is a pro-inflammatory cytokine involved in H. pylori-induced gastric inflammation. Therefore, w...

background the incidence rate of gastric cancer in western countries has shown a remarkable decline in the recent years while it is still the most common cancer among males in iran. the proto-oncogene myc, located at 8q24.1, regulates almost 15% of human genes and is activated in 20% of all tumors. the amplification of myc and overexpression of its protein product are observed in 15 - 30% of ga...

Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics probably involved in gastric cancer incidence through activation of procarcinogens. North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds, including agricultural pesticides, are massively used. In this report, we quantitatively...

gastric cancer (gc) is the second most common cancer in the world and a leading cause of cancer-related mortality. methylation of promoter cpg islands (cgis) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding genes leading to carcinogenesis and other disorders. adenomatous polyposis coli (apc) a tumor suppressor gene is inactivated by methylation of prom...

Gastric cancer is one of the deadliest malignant tumors, and recent studies have confirmed clinical efficacy acupuncture in treatment gastric cancer, which has been recognized widely carried out practice both at home abroad, while less research conducted on mechanism cancer. By reviewing anti-gastric effects years, we categorized summarized from regulating intestinal flora, body immunity, tumor...

oxidative stress is known to be one of the major factors involved in the development and progression of cancer. oxidative stress can occur due to an imbalance between concentrations of reactive oxygen species and antioxidant capacities. catalase (cat; omim 115500) and superoxide dismutase 1 (sod1; omim 147450) play important roles in the primary defense against oxidative stress. in the present ...