We develop an analytic statistical framework for examining a variety of gene-set enrichment analysis tests. Within this framework, we describe why statistical power for both self-contained and competitive gene set tests is a function of the correlation structure of co-expressed genes, and why this characteristic is undesireable for gene-set analyses. We additionally describe why past gene-set t...

canine distemper virus (cdv) creates a very contagious viral multi-systemic canine distemper (cd) disease that affects most species of carnivora order. the virus is genetically heterogeneous, particularly in section of the hemagglutinin (h) gene. sequence analysis of the h gene can be useful to investigate distinction of various lineages related to geographical distribution and cdv molecular ep...

Enrichment analysis of gene sets is a popular approach that provides a functional interpretation of genome-wide expression data. Existing tests are affected by inter-gene correlations, resulting in a high Type I error. The most widely used test, Gene Set Enrichment Analysis, relies on computationally intensive permutations of sample labels to generate a null distribution that preserves gene-gen...