objectives:crocin is one of constituents of saffron and has antioxidant property. zinc chloride is one of the common compounds of zinc with antioxidant activity. the present study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats. materials and methods:diabetes was induced ...

introduction: oral delivery is the most favorable route for insulin administration. the aim of this study was to generate new chitosan coated insulin nanoliposomes and then to assess the physiological efficacy of these nanoliposomes after oral administration in diabetic rabbits. methods: nanoliposomes with negative surface charge encapsulating insulin were prepared by reverse phase evaporation ...

Type II Diabetes mellitus (T2DM) is the most common of two types disease. T2DM a metabolic disease characterized mainly by insulin resistance, reduction secretion, and hyperglycemia. major public health cause concern not only increase in morbidity mortality associated with patients disease, but also significant quality life productivity among economically active population. Isolated hyperglycem...

BACKGROUND: Equine metabolic syndrome is an endocrinopathy that affects different breeds of horses and ponies. This metabolic disorder is a multifactorial syndrome and it is primarily linked to obesity, dyslipidemia and insulin resistance. OBJECTIVES: The present study was performed to evaluate insulin resistance in Darehshori horses with regards to age, sex, season and obesity. METHODS: Twelve...

INTRODUCTION Neonatal hyperglycaemia is frequently treated with insulin, which may increase the risk of hypoglycaemia. Computer-determined dosage of insulin (CDD) with the STAR-GRYPHON program uses a computer model to predict an effective dose of insulin to treat hyperglycaemia while minimising the risk of hypoglycaemia. However, CDD models can require more frequent blood glucose testing than c...

recently, the role of myostatin (mstn) in controlling insulin resistance (ir( has been known. the aim of this study was to determine acute and delayed response of mstn and ir to circuit resistance exercise. for this purpose, 12 healthy men volunteered and participated in 2 sessions of the resistance exercise and control with one-week interval. after a session to instruct how to perform resistan...

Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic r...