Tangelos are citrus hybrids with grapefruit and tangerine parentage and are a significant crop in Florida, marketed as specialty fruit. Because tangelos contain genetic material from grapefruit, there is the question of whether or not they contain furanocoumarins and exhibit an interaction with the drugs that have been associated with the grapefruit-drug interaction. Authentic samples of 13 tan...

Grapefruit juice produces mechanism-based inhibition of intestinal drug metabolism when consumed in normal quantities. This can produce clinically important increases in oral drug bioavailability when coadministered with substrates of cytochrome p450 3A4 (CYP3A4) that undergo high presystemic metabolism. Furanocoumarins such as bergamottin and 6',7'-dihydroxybergamottin have been identified as ...

Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P - 450 3A4 system, which is responsible for the first pass metabolism of many drugs. The P - glycoprotein pump, found in the brush border of the intestinal wall which transports many of these...

As a by-product, fruit peel can extract a variety of active ingredients, it has great value, which can turn waste into treasure and improve the utilization rate of raw materials. Orange peel, pomelo peel, banana peel and granatum are the main fruit peel utilize in China, This review focuses on the function, extracting ways and application of some components in this fruit peel. In order to make ...

BACKGROUND Differences in tea drinking habits and/or citrus peel use are likely to vary by populations and could contribute to the inconsistencies found between studies comparing their consumption and cancer risk. METHODS A population-based case-control study was used to evaluate the relationships between citrus peel use and black tea intake and squamous cell carcinoma (SCC) of the skin. More...

Tramadol is a centrally acting analgesic drug extensively metabolized in animal species. Its clinicalresponse is mainly due to the M1 metabolite, poorly produced in dogs. Grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. The aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...

The failure of an adhesive layer in a 180° peel test is analyzed by the modeling of the peel as an elastica. The adhesive is assumed to fail by a process of cavitation and fibrillation. The resistance of the fibrillated material to deformation gives rise to a rate-dependent peel force F. Governing equations, which take into account the large deformation of the fibrillated materials, are derived...