Gastric hemangioma in the neonatal period is a very rare cause of upper gastrointestinal bleeding. We present a case of hemangioma limited to the gastric cavity in a 10-day-old infant. A huge, erythematous mass with bleeding was observed on the lesser curvature side of the upper part of the stomach. Surgical resection was ruled out because the location of the lesion was too close to the gastroe...

Background:   H2-EB1 molecule which is the homolog of Human HLA-DRB1 is proposed to be associated with allergic rhinitis (AR). Construction of   H2-Eb1 knockout animal models provides a tool to elucidate the role of H2-EB1 and AR pathogenesis. Objective:   To establish the H2-Eb1 knockout model and investigate the H2-EB1 functions in   H2-Eb1 knockout mice as a model of AR. Methods: The Cre/Lox...

(2011) Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution licence and may be reused according to the conditions of the licence. For more details see: ...

Ligand-independent signaling by the angiotensin II type 1 receptor (AT1R) can be activated in clinical settings by mechanical stretch and autoantibodies as well as receptor mutations. Transition of the AT1R to the activated state is known to lower inverse agonistic efficacy of clinically used AT1R blockers (ARBs). The structure-function basis for reduced efficacy of inverse agonists is a fundam...

About 1.5-6 % of the patients with gastric and duodenal erosions admitted to I.C.U. are prone to gastrointestinal (G.I.) bleeding with its ensuing complications. Routine prophylaxis with H2-blockers and anti-acid has been used in these high risk patients for decades.In this study we evaluated the effect of P.O omeprazole, a potent acid inhibitor with prolong effects on gastric pH.  Patients wit...

background:   h2-eb1 molecule which is the homolog of human hla-drb1 is proposed to be associated with allergic rhinitis (ar). construction of   h2-eb1 knockout animal models provides a tool to elucidate the role of h2-eb1 and ar pathogenesis. objective:   to establish the h2-eb1 knockout model and investigate the h2-eb1 functions in   h2-eb1 knockout mice as a model of ar. methods: the cre/lox...

Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...

mfi-type zeolite membranes (zsm-5) were prepared on α-alumina tubular supports and tested for separation of h2/co mixtures. the effect of pressure and temperature on h2 and co flows and selectivity was investigated. the best results in this work were obtained with a zsm-5 membrane prepared over a porous α-alumina tube seeded with zeolite nanocrystals synthesized with microwave technique. in thi...

Correspondence to: Sun-Young Lee Department of Internal Medicine, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-729, Korea Tel: +82-2-2030-7505, Fax: +82-2-2030-7748, E-mail: [email protected] pISSN 1976-2283 eISSN 2005-1212 http://dx.doi.org/10.5009/gnl14499 Helicobacter pylori is a major cause of peptic ulcer disease (PUD) recurrence, and thus eradication is ...

Background: As time evolved, traditional Chinese medicine (TCM) became integrated into the global medical system as complementary treatments. Some essential TCM herbs started to play a limited role in clinical practices because of Western medication development. For example, Fuzi (Aconiti Lateralis Radix Praeparata) is toxic but indispensable herb. was mainly used poor circulation and life-thre...