introduction: omperazole as a very useful drug in peptic ulcer which needs to be converted to active form and its activation requires acidic enviornments. h2 blockers and antacids can prevent this activation by elevation of ph in the gastrointestinal system thus diminishing omperazole effectiveness. in this study, cases of coadministration of omperazsole with h2 blockers and antiacids has been ...

BACKGROUND The policy of prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal mucosal injury is still a matter of discussion. Indeed, no consensus exists as to whether cotherapy with histamine type 2 (H2) blockers or misoprostol is cost-effective. METHODS Placebo-controlled randomized clinical trials on the use of H2 blockers or misoprostol, as preventive agents ...

CONTEXT Projected cost for lansoprazole, the formulary proton pump inhibitor (PPI) at our institution, was $1.8 million in 1999. While some patients require PPI therapy, many could control their symptoms with a histamine H2-receptor antagonist blocker (H2 blocker) at a much lower cost. OBJECTIVE To evaluate a practice-based approach to converting patients from PPIs to H2 blockers. DESIGN Be...

Gastric ulcer is relatively infrequent, and clinical trails are often based on small-sized samples. The aim of this study was to define the "gold standard" therapy of active gastric ulcer. We included all single- or double-blind clinical trials on the short-term treatment of gastric ulcer. All the articles published over the period 1977-1994 were reviewed. Meta-analysis was done with both fixed...

the role of endogenous histamine and h1, h2 and h3 central receptors on food intake in broiler chickenswas investigated. for this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (icv) injection of thioperamide, an h3 receptor antagonist, and r-α-methylhistamine, an h3 receptor agonist and subsequently the effects of brain histaminergic...

BACKGROUND It is unclear if histamine H2 receptor antagonists (H2 blockers) prevent a variety of gastrointestinal harms among patients taking acetylsalicylic acid (ASA) over long periods. METHODS Electronic databases (e.g., MEDLINE, Embase and Cochrane Central Register of Controlled Trials; from inception to November 2010) and reference lists of retrieved articles were searched. Randomized pl...

The role of endogenous histamine and H1, H2 and H3 central receptors on food intake in broiler chickenswas investigated. For this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-α-methylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic...