May-October 2004, influenza A (H3N2) viruses circulated worldwide and were associated with mild-to-moderate levels of disease activity. Influenza A (H1N1) and B viruses were reported less frequently. In North America, isolates of influenza A (H3N2), A (H1N1), and B were identified sporadically. This report summarizes influenza activity in the United States and worldwide during May-October 2004....

background in the influenza a viruses, neuraminidase (na), hemagglutinin (ha), pb2, ns1 and m are responsible for the disease pathogenicity. the mechanism of pathogenicity differs among these viruses. binding of host proteases by the viral na, sequence of ha in the cleavage and receptor-binding sites, number of oligosaccharide side chains of ha, shortening of na, and substitutions in pb2, ns1 a...

To the editor: The recent paper by Thompson et al. [1] highlighted the detection of influenza A (H3N2) virus in oral fluids from children with a clinical diagnosis of mumps. They concluded that influenza A(H3N2) virus should be considered as part of the differential diagnosis for mumps-like illness, particularly during influenza outbreaks caused by drifted strains. We report here similar findin...

Prior to serological testing, influenza viruses are typically propagated in eggs or cell culture. Recent human H3N2 strains bind to cells with low avidity. Here, we isolated nine primary H3N2 viral isolates from respiratory secretions of children. Upon propagation in vitro, five of these isolates acquired hemagglutinin or neuraminidase mutations that increased virus binding to cell surfaces. Th...

Background. Influenza causes various seasonal respiratory diseases, resulting in significant morbidity and mortality children. is a highly contagious disease causing global pandemics. This study aimed to investigate the frequency outcome of influenza children admitted Tabriz Children's Hospital. Methods. cross-sectional included suspected patients Medical Center between 2014 2019 diagnosed with...

Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs o...

A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC5...

Influenza surveillance networks in Guangdong were established to investigate the epidemiological characteristics of influenza and influenza epidemics. Influenza activity peaked annually from March to July in Guangdong in 1991-2000; influenza H3N2 predominated in the epidemic (7 years of 10); the outbreak of influenza in 1996 was the remarkable result of antigenic drift of H3N2 strain. Ten isola...

Live-attenuated influenza virus (LAIV) prime-boost vaccination previously conferred protection against heterologous H3N2 swine influenza challenge, including in piglets with maternally derived antibodies (MDA). Conversely, a whole-inactivated virus (WIV) vaccine was associated with enhanced disease. This study was aimed at identifying immune correlates of cross-protection. Piglets with and with...

The influenza A(H3N2) virus has circulated worldwide for almost five decades and is the dominant subtype in most seasonal influenza epidemics, as occurred in the 2014 season in South America. In this study we evaluate five whole genome sequences of influenza A(H3N2) viruses detected in patients with mild illness collected from January-March 2014. To sequence the genomes, a new generation sequen...