Recent studies suggest hat treatment of hemophiliacs with highly purified factor Vlll concentrates may preserve immune function. To test this hypothesis, we prospectively studied 51 hemophilic patients (21 human immunodeficiency virus [HIVI seropositive and 30 seronegative) who were on home therapy exclusively with recombinant factor Vlll (Kogenate, Miles Laboratory, Berkeley, CA) for 3.5 years...

The purpose of this pictorial assay is to demonstrate the imaging features of the various musculoskeletal manifestations of hemophilia, an X-linked disorder. Depending on the site of recurrent bleeding, musculoskeletal manifestation can be in the form of hemophilic arthropathy and/or soft tissue, intraosseous, or subperiosteal pseudotumors. Radiography, sonography, computed tomography, and espe...

1. The hemophilic bacilli can be divided into two large groups according to the ability of certain strains to produce hemolysis. 2. Both the hemolytic and the non-hemolytic groups may be further subdivided according to the ability of some strains to produce indole, to form gas, and to ferment certain carbohydrates. 3. The hemophilic bacilli of both the hemolytic and the non-hemolytic varieties ...

intracranial hemorrhage and entrapment neuropathy are the most serious and disabling complications in hemophilia.the occurance of these neurological complications was studied in 214 hemophiliac patients during a 3 month period. nine patients (4.2%) suffered intracranial hemorrhage (one epidural and others intracerebral). all of intracranial hemorrhage patients had the sevee form of disease (<1%...

F.Giannelli, P.M.Green, K.A.High, S.Sommer, D.P.Lillicrap, M.Ludwig, K.OIek, P.H.Reitsma, M.Goossens, A.Yoshioka and G.G.Brownlee* Paediatric Research Unit, Guy's Tower, London Bridge, London SE1 9RT, UK, School of Medicine, Division of Hematology, University of North Carolina, Chapel Hill, NC 27599, Mayo Clinic, 200 Southwest First Street, Rochester, MN 55905, USA, department of Pathology, Ric...

In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process?

Antihemophilic factor (AHF, factor VIII) is a macromolecule that can be dissociated into two subcomponents. One, of high molecular weight (MW), forms precipitates with heterologous antiserum against AHF and supports ristocetin-induced aggregation of platelets. The other, of lower MW, has procoagulant activity. The plasma of patients with classic hemophilia contains a form of AHF with properties...