Our recent experimental work demonstrated that a neutrophil-dependent inflammatory response in the lung prevented the normal up-regulation of alveolar fluid clearance by catecholamines following hemorrhagic shock. In this study, we tested the hypothesis that the release of NO within the airspaces of the lung was responsible for the shock-mediated failure of the alveolar epithelium to respond to...

Shahani, Rohan, John G. Marshall, Barry B. Rubin, Ren-Ke Li, Paul M. Walker, and Thomas F. Lindsay. Role of TNF-a in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia. Am. J. Physiol. Heart Circ. Physiol. 278: H942–H950, 2000.—Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50–70% mortality...

Shahani, Rohan, John G. Marshall, Barry B. Rubin, Ren-Ke Li, Paul M. Walker, and Thomas F. Lindsay. Role of TNF-a in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia. Am. J. Physiol. Heart Circ. Physiol. 278: H942–H950, 2000.—Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50–70% mortality...

Treatment of hemorrhagic shock continues to evolve. Surgically, the concept of "damage control" has become the standard, with shorter operations focused on the control of life-threatening injuries. For the anesthesiologist, practice has changed, with a better understanding of the pathophysiology of shock, new techniques such as deliberate hypotension and perfusion-focused therapy, improved mana...

When endotoxins are given intravenously the granulocytes leave the active stream of the circulation and congregate chiefly in the capillaries of the lung, spleen and liver. The same phenomenon can be expected to occur in hemorrhagic shock because experimental evidence suggests that the loss of the antibacterial defenses in shock results in the development of an endotoxemia (1). This paper prese...

Vascular hyporeactivity is an important factor in irreversible shock, and post-shock mesenteric lymph (PSML) blockade improves vascular reactivity after hemorrhagic shock. This study explored the possible involvement of myosin light chain kinase (MLCK) in PSML-mediated vascular hyporeactivity and calcium desensitization. Rats were divided into sham (n=12), shock (n=18), and shock+drainage (n=18...

There has been recent interest in resuscitation of hemorrhagic shock using new colloid solutions such as Hextend (6% hydroxyethyl starch in balanced salt solution). We examined the effects of resuscitation of porcine hemorrhagic shock with Hextend or lactated Ringer’s (LR) solution on hemodynamic parameters and tissue energetics. Anesthetized, instrumented pigs underwent hemorrhagic shock (35% ...

BACKGROUND S100B protein in patients with cardiac arrest, hemorrhagic shock and other causes of global cerebral ischemic injury will be dramatically increased. Ischemic brain injury may elevate the level of serum S100B protein and the severity of brain damage. METHODS This article is a critical and descriptive review on S100B protein in serum after ischemic brain injury. We searched Pubmed da...

Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50-70% mortality. Myocardial dysfunction may contribute to the high rate of mortality after aneurysm repair. We attempted to determine whether RAAA repair results in cardiac dysfunction mediated by tumor necrosis factor-alpha (TNF-alpha). We modeled aortic rupture ...