Low levels of n-3 polyunsaturated fatty acids (PUFAs) in serum and liver tissue biopsies are the common characteristics in patients with alcoholic liver disease. The α-linolenic acid (ALA) is a plant-derived n-3 PUFA and is rich in flaxseed oil. However, the impact of ALA on alcoholic fatty liver is largely unknown. In this study, we assessed the potential protective effects of ALA-rich flaxsee...

Hepatic endometriosis is a very rare medical condition characterized by the implantation of ectopic endometrial tissue within the hepatic parenchyma. Preoperative diagnosis is difficult via cross-sectional imaging and histopathologic evaluation remains the gold standard for diagnosis. We report a case of hepatic endometrioma in a 44-year-old woman with history of endometriosis. The literature i...

BACKGROUND Osteopontin (OPN) plays an important role in the progression of chronic liver diseases. We aimed to quantify the liver, adipose tissue and serum levels of OPN in heavy alcohol drinkers and to compare them with the histological severity of hepatic inflammation and fibrosis. METHODOLOGY/PRINCIPAL FINDINGS OPN was evaluated in the serum of a retrospective and prospective group of 109 ...

OBJECTIVE To investigate whether emulsified isoflurane preconditioning could reduce lung injury induced by hepatic I/R in rats and its mechanism. MATERIALS AND METHODS 32 pentobarbital-anesthetized Sprague-Dawley rats were equally randomized into four groups: laparotomy group (Sham group), hepatic I/R and normal saline infusion group (I/R+S group), I/R and lipid vehicle infusion (I/R+V group)...

These studies were conducted to assess the relationship between visceral adipose tissue free fatty acid (FFA) release and splanchnic FFA release. Steady-state splanchnic bed palmitate ([9,10-(3)H]palmitate) kinetics were determined from 14 sampling intervals from eight dogs with chronic indwelling arterial, portal vein, and hepatic vein catheters. We tested a model designed to predict the propo...

Hepatic lymphangioma is a rare benign neoplasm characterized by cystic dilatation of the lymphatic vessels in the hepatic parenchyma. In most cases, the hepatic lesion is a part of multi-organ involvement including the liver, spleen, kidneys, skeleton, gastrointestinal tract, mesentery, lungs, and somatic soft tissue. The typical imaging feature of hepatic lymphangioma is a cystic or multicysti...

Aims: Both ischemia and reperfusion (IR) can cause damages in cells. There are several studies to eliminate the damage. Tirofiban Hydrochloride (TH) is a common glycoprotein IIb/IIIa inhibitor and is being used for ischemic disorders for many years. We aimed to determine the therapeutic effects of tirofiban in liver ischemia reperfusion injury model in this animal study. Materials and methods: ...

UNLABELLED Accurate quantification of regional liver function is needed, and PET of specific hepatic metabolic pathways offers a unique method for this purpose. Here, we quantify hepatic galactose elimination in humans using PET and the galactose analog 2-(18)F-fluoro-2-deoxy-d-galactose ((18)F-FDGal) as the PET tracer. METHODS Eight healthy human subjects underwent (18)F-FDGal PET/CT of the ...

The microcirculation of the liver has important roles in maintenance of liver function. It guarantees the supply of the parenchymal tissue with oxygen and nutrients, serves as the gate for leukocyte entrance in hepatic inflammation, and is responsible for the clearance of toxic materials and foreign bodies from the bloodstream. The morphology and physiology of the hepatic microcirculation are d...