Identification of genes determining narcolepsy susceptibility is important not only for understanding that disorder but also for possible clues to general sleep-control mechanisms. Studies in humans reveal at least one such gene related to the major histocompatibility complex and in dog an as-yet-unmapped single, autosomal recessive gene canarc-1. Gene markers for canarc-1 were therefore sought...

Graft rejection frequencies in a population of the sponge Ectyoplasia ferox are reported in relation ta the complexity of the histocompatibility system in this species. The frequency of graft acceptance is high but we show that, despite assumptions in the literature to the contrary, this does not imply that sponges accepting each other’s grafts are genetically identical. This paper reports that...

Cytotoxic T-lymphocytes (CTLs) specific for autologous human squamous cell cancer of the lung were generated by stimulation of peripheral blood lymphocytes with autologous tumor cells in vitro. The CTL line was >97% CD3+, CD8+, CD16- and produced tumor necrosis factor-alpha, gamma-interferon, and granulocyte-macrophage colony-stimulating factor after stimulation with autologous tumor. The CTLs ...

HL-A antigens are gene products of the major histocompatibility locus in man (i). These cell surface antigens are the human counterparts of the H-2 (2,3), AgB (4), CHL-A (5), and DL-A (6) antigen systems in mice, rats, chimpanzees, and dogs, respectively, In the past few years there have been considerable efforts to elucidate the genetic and chemical characteristics of the various HL-A antigens...

BACKGROUND Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. T cells recognizing hematopoietic restricted minor histocompatibility antigens may induce selective gr...

BACKGROUND Increasing evidence implicates immune response as a contributing factor in the failure of allograft valve transplants. Increases in panel reactive antibodies have been identified in human subjects. To correlate these responses with novel preimplantation processing methods to reduce cellularity, both a relevant panel reactive antibody assay and a chronic implantation animal model are ...

Over 50 HLA antigens are now recognisable. Since we each have four antigens there are millions of possible combinations that characterise us as individuals. In humans these antigens are coded for in the major histocompatibility complex on the sixth chromosome. The loci for three of the complement components (C2, C4, and factor B) are in or near the major histocompatibility complex. In mice and ...

Insulin-dependent diabetes mellitus is often accompanied by manifestations of autoimmunity and is frequently associated with certain HLA haplotypes, predominantly DR3 and DR4. Because the major histocompatibility antigens are important determinants of the immune response in various tissues, we have investigated their expression on the pancreatic islet cells. Human, mouse, or rat islets of Lange...

PURPOSE To determine whether anterior chamber-associated immune deviation (ACAID) promotes corneal allograft survival. METHODS CB6F1 mice were grafted with orthotopic corneal transplants from C3H donors (mismatch at the entire major histocompatibility complex plus multiple minor histocompatibility loci) and from NZB donors (mismatch only at multiple minor histocompatibility loci). ACAID was i...