OBJECTIVE ET-26 HCl is a promising sedative-hypnotic anesthetic with virtually no effect on adrenocortical steroid synthesis. However, whether or not ET-26 HCl also has a sufficiently wide safety margin and hemodynamic stability similar to that of etomidate and related compounds remains unknown. In this study, the effects of ET-26 HCl, etomidate and propofol on therapeutic index, heart rate (HR...

An MCF-7 human breast cancer cell line was selected which was 200fold more resistant to Adriamycin than the wild type cell line. This Adriamycin-resistant (Adr") cell line exhibited a multidrug-resistant phenotype and was cross-resistant to a wide range of antineoplastic agents including Vinca alkaloids, anthracyclines, and epipodophyllotoxins. Cytogenetic analysis of the Adr" cell line showed ...

This paper addresses the performance evaluation of the multiple input multiple output (MIMO) precoding technique, referred to as max-dmin precoding, over fading channel with impulsive noise in a railway tunnel. Measurements showed that the received signal at the antenna on the moving train roof near the catenary suffers from electromagnetic noise interference (EMI). This implies that the tradit...

We compared maximum displacement thresholds (Dmax) with minimum displacement thresholds (Dmin) in patients with retinitis pigmentosa (RP) in order to characterize the nature of their visual disability, as well as to assess possible models of foveal vision loss. Thresholds for discriminating the direction of the spatial displacement of random dot patterns were measured in a group of 20 patients ...

Gene amplification may be visualized within a chromosome as a homogeneously stained region (HSR) and HSRs have rarely been reported in human tumor cells with identification of the amplified gene. A parental line and seven clones derived from KB cells resistant to methotrexate (MTX) contain dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase; EC 1.5.1.3), ranging from 0.007 unit/mg in ...

We consider the mean distribution functions Φ(r|l), ΦB(r|l), and ΦS(r|l), giving the probability that two sites on the incipient percolation cluster, on its backbone and on its skeleton, respectively, connected by a shortest path of length l are separated by an Euclidean distance r. Following a scaling argument due to de Gennes for self-avoiding walks, we derive analytical expressions for the e...

A graph G is called a pairwise compatibility graph (PCG) if there exists an edge weighted tree T and two non-negative real numbers dmin and dmax such that each leaf lu of T corresponds to a vertex u ∈ V and there is an edge (u, v) ∈ E if and only if dmin ≤ dT (lu, lv) ≤ dmax where dT (lu, lv) is the sum of the weights of the edges on the unique path from lu to lv in T . In this paper we analyze...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in 1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). The MYC gene at 8q24 has been reported to be amplified in the majority of the cases, and generally it has been assumed that MYC is the target gene. However, only a few studies have focused on the extent of the amp...

Recently, Horrireich, Luban and Shtrikman have / used renormalization group techniques to discuss the ~ d~/,,= 1. (3) onset of helical okder inmagnetic systems [1, 2]. lii i 1 particular, the existence of new types of critical beFor o~= 2 these conditions reduce to those given prehavior has been p~stulatedfor the “Lifshitz” point viously [5, 6]. In some cases (such as isotropic propawhere the t...