Inclement weather at an airline's hub airport can be devastating to that airline's schedule. The repercussions resonate throughout the airline's network as capacity is reduced, connections are missed, and passengers are delayed on a larger scale than during irregular operations at a spoke airport. The main hypothesis behind the work presented in this thesis is that by shifting a small fraction ...

Introduction The Airline Deregulation Act (ADA) of 1978 caused many changes in the industry. For the first time in 40 years, new airlines were permitted to enter the industry, and all airlines could choose the routes they would serve and the fares they would charge. Airlines were also free to exit the industry (go bankrupt), if they made poor choices in these matters. Naturally, this has led to...

Purpose: The objective of this research is to identify and characterize the coordination systems used by SME hub firms that are in a situation of dependence with respect to other members of their network, taking into account the influence of hub firm size. Design/methodology/approach: Seven case studies were carried out: six innovation networks in which SMEs play a central role are compared wit...

Hub location problems are strategic network planning problems. They formalise the challenge of mutually exchanging shipments between a large set of depots. The aim is to choose a set of hubs (out of a given set of possible hubs) and connect every depot to a hub so that the total transport costs for exchanging shipments between the depots are minimised. In classical hub location problems, the un...

Serviços de Radiologia, Otorrinolaringologia e Genética Clínica do Hospital Universitário de Brasília, Universidade de Brasília (UnB), Brasília DF, Brazil: Médica Residente de Radiologia e Diagnóstico por Imagem, Hospital Universitário de Brasília (HUB), Universidade de Brasília (UnB); Médico Neurorradiologista, Doutorando do Programa de Pós-graduação em Ciências Médicas da Faculdade de Medicin...

Identification of hub proteins from sequence is a challenge in molecular biology. Therefore, it is of interest to predict protein hubs in networks. We describe the prediction of protein "hub" using physiochemical, thermodynamic and conformational properties of amino acid residues in sequence. We have used twenty sequence based features to identify hub behaviour. Linear discriminant analysis and...

The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson's disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Re...

Hepatocellular carcinoma (HCC) has a high incidence and mortality worldwide, and its carcinogenesis and progression are influenced by a complex network of gene interactions. A weighted gene co-expression network was constructed to identify gene modules associated with the clinical traits in HCC (n = 214). Among the 13 modules, high correlation was only found between the red module and metastasi...

Centralizing and using proper transportation facilities cut down costs and traffic. Hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. A distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...