نتایج جستجو برای: human ige
تعداد نتایج: 1655404 فیلتر نتایج به سال:
We investigated the capacity of Staphylococcus aureus Cowan 1 and S. aureus Wood 46 to induce histamine release from human basophils in vitro. S. aureus Cowan 1 (10(5) to 10(7)/ml), which synthesizes protein A (Staph A), stimulated the release of histamine from basophils, whereas S. aureus Wood 46 (10(5) to 2 X 10(7)/ml), which does not synthesize Staph A, did not induce histamine secretion. So...
Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been shown to elicit mast cell activation in an antigen-independent cytokinergic mann...
human basophils play a key role in allergic diseases such as asthma and in a variety of immunological disorders. the generation of il-4 and il-13 can be induced from basophil by ige-mediated and non-ige-mediated mechanisms. time and stimulus- dependent differences in the regulation of these cytokines could have relevance to their biological effects. the aim o...
© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Immediate type hypersensitivity reactions can occur after allergen exposure followed by allergen-specific IgE-FcεRI interactions on mast cells/basophils in sensitized subjects. In comparison, chronic allergic inflammation induced by Th1 re...
سابقه و هدف: سندرم Hyper IgE بیماری نادری از دسته سندرمهای کمبود ایمنی اولیه است که با مشخصات عفونتهای ریوی و جلدی، اگزما و افزایش سطح سرمی IgE مشخص میشود. در این مقاله، 4 بیمار مبتلا به عفونتهای متعدد ریوی در زمینه سندرم Hyper IgE. معرفی میگردند. معرفی مورد: در این مطالعه 4 دختر که سابقه عفونتهای ریوی متعدد داشتند، بررسی شدند و در نهایت سندرم Hyper IgE در آنها تشخیص داده شد. در تمامی ...
BACKGROUND Initiated and regulated by mast cells, allergic responses are balanced through an intricate network of positive and negative signals. We have recently shown that the inhibitory receptor CD300a is expressed on human mast cells and modulates a large array of their functions. OBJECTIVE We sought to evaluate CD300a as a negative regulator of allergic inflammation in vivo by means of a ...
The link between IL-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. At the present study, we address the role of B cell derived IL-13 in the IgE and other immunoglobulin development. Antisense oligo for human IL-13 mRNA was used to study IgE down regulation. Human B-lymphocytes were purified by positive selectio...
We present evidence for RNA transcripts encoding two forms of human e immunoglobulin (Ig) heavy chain that differ significantly from those of other isotypes. We previously demonstrated three human e mRNA species, instead of the two, corresponding to membrane and secreted proteins, seen with other heavy chain transcripts. In human genomic DNA downstream of the Ce gene, we identified sequences ho...
The low-affinity IgE receptor FcϵRII (CD23) is part of the regulatory system controlling IgE synthesis in human B cells and exists in membrane and soluble forms. Binding of IgE to CD23 has been described to have stabilizing effects and to prevent cleavage of CD23. Previous experiments using anti-CD23 antibodies reduced IgE synthesis but were difficult to interpret as the antibody Fc part might ...
We present evidence for RNA transcripts encoding two forms of human epsilon immunoglobulin (Ig) heavy chain that differ significantly from those of other isotypes. We previously demonstrated three human epsilon mRNA species, instead of the two, corresponding to membrane and secreted proteins, seen with other heavy chain transcripts. In human genomic DNA downstream of the C epsilon gene, we iden...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید