نتایج جستجو برای: human offspring
تعداد نتایج: 1670406 فیلتر نتایج به سال:
In this review, we critically assess recent evidence from human studies regarding the potential implications of exposure to maternal diabetes in-utero for long-term adiposity, cardiometabolic outcomes, and cognitive ability of the offspring. Evidence supports a direct causal role for exposure to maternal diabetes in utero in determining offspring long-term greater adiposity and adverse cardiome...
Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited ...
background: over the past several years, mammals have been successfully cloned by either the splitting of an early stage embryo or nuclear transfer of adult somatic cells (nt) into oocytes. although it has been 15 years since the generation of the first cloned mammals from somatic cells by nt, the success rate for producing live offspring by this technique is low regardless of the cell type and...
BACKGROUND Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation). OBJECTIVE Because of limited opportunities for prospective studies in children, we tested whether exposure to moderate stress early in life produces later stress resistance in a primate model. DESIGN ...
BACKGROUND Animal studies have shown that protein intake in pregnancy may influence offspring fat metabolism and adiposity. The macronutrient ratio in human pregnancy appears to be important for offspring glucose tolerance; however, less is known about the influence on offspring adiposity. OBJECTIVE We examined the relation between maternal dietary protein intake during pregnancy and offsprin...
BACKGROUND Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. METHODS Of 1782 reproductive-aged women dete...
Background: Alpha Methyldopa (AMD) is a well-known treatment for the pregnancy induced hypertension and commonly used in several countries. Indeed the possible effect of AMD on the behavioral activities of offspring, whom are exposed during fetus period, has not been studied. The present study evaluated the possible effect of maternal administration of AMD on the rat offspring memory in the gro...
Preeclampsia affects between 4 to 8% of all human pregnancies. It compromised both mothers and offspring beyond perinatal period. This is the first o two papers related whit this phenomenon and shows the available evidence about the effect of preeclampsia over the preeclamptic offspring from cohort studies. It is devoted to develop all facts related with respiratory distress syndrome, sepsis, n...
Rather than being a passive, haphazard process of wear and tear, lifespan can be modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in laboratory animals. Complete or partial loss-of-function mutations in genes encoding components of the insulin/IGFI pathway result in extension of life span in yeasts, worms, flies, and mice. This remarkable conservation ...
SUSAN MOLLER OKIN, IN her 1989 book Justice, Gender, and the Family, puts forth an objection to Nozick’s entitlement theory. In short, Nozick's entitlement theory states that unowned material resources can be legitimately acquired by labor in a certain sense. Okin argues that an advocate of Nozick’s entitlement theory must, on pain of contradiction, accept that a mother owns her offspring by vi...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید