The Na(+)/Ca(2+) exchanger (NCX) is a bidirectional transporter that is controlled by membrane potential and transmembrane gradients of Na(+) and Ca(2+). Although two isoforms of NCX1 and NCX2 are coexpressed on the basolateral membrane of the distal nephron, the functional significance of these isoforms is not entirely clear. Therefore, we used NCX1- and NCX2-heterozygote knockout mice (KO) an...

The epithelial Ca(2+) channel TRPV5 serves as a gatekeeper for active Ca(2+) reabsorption in the distal convoluted tubule and connecting tubule of the kidney. WNK4, a protein serine/threonine kinase with gene mutations that cause familial hyperkalemic hypertension (FHH), including a subtype with hypercalciuria, is also localized in the distal tubule of the nephron. To understand the role of WNK...

Background: Renal stone (RS) is a highly prevalent disease in our societies and mostly secondary to lifestyle habits. HIV1 patients often experience RS, although specific risk factors are not known. Despite other priorities, comprehensive work-up should be offered avoid recurrences (50% 5 years). Purpose Methods: The aim of the study describe how handle RS persons living with suggest understand...

Brushite (CaHPO(4).2H(2)O) was considered to govern the formation of renal calculus of calcium phosphate origin. The degree of saturation of urine with respect to this phase was therefore calculated. This value was obtained from the ratio of the activity product of Ca(++) and HPO(4) (m) (K(sp)) before and after incubation of urine with brushite. The errors in the calculation of K(sp) were large...

in spite of vast improvements in urinary stone treatment (eswl, pnl, ureteroscopy, etc.), metabolic workup concerning the existence of stone forming risk factors are of great importance and can lead to control and even prevention of urinary stone formation in these patients. in this analytical case-control study performed on 266 persons [110 normal persons (56 males and 54 females), 76 patients...

Hypercalciuria with or without hypercalcemia is a well-known complication of sarcoidosis, the pathogenesis of which is not fully understood. Pregnancy is associated with physiologic alterations in calcium metabolism. These changes can further alter the derangement of calcium metabolism that occurs in sarcoidosis, if the two conditions coexist. We had the opportunity to study prospectively the c...