FINAL PHYSIOLOGICAL REGULATION of eating resides in the hypothalamus. There signals from the periphery (e.g., leptin, insulin, glucose) activate and inhibit circuits that drive ingestive behavior. Thus leptin and insulin act on neurons in the arcuate nucleus. Leptin inhibits neurons that coexpress neuropeptide Y (NPY) and agouti-related peptide (AGRP) and also activates proopiomelanocortin (POM...

Most forms of hypertension are associated with a wide variety of functional changes in the hypothalamus. Alterations in the following substances are discussed: catecholamines, acetylcholine, angiotensin II, natriuretic peptides, vasopressin, nitric oxide, serotonin, GABA, ouabain, neuropeptide Y, opioids, bradykinin, thyrotropin-releasing factor, vasoactive intestinal polypeptide, tachykinins, ...

Endocrine disputer chemicals (EDCs) such as 4-tert-octylphenol (OP), are a class of exogenous pollutants that can interfere with normal physiological processes, resulting in number health issues. Therefore, the goal current study is to determine how well α -lipoic acid (LA) protects against DNA damage brought on by OP. Forty male albino rats were randomly assigned into four groups. Group I (con...

3 Diseases ................................................................................. 17 3.1 Anterior Pituitary Deficiency................................................ 17 3.2 Central Diabetes Insipidus .................................................... 21 3.3 Precocious or Delayed Puberty............................................. 23 3.4 Other Endocrinopathies .......................

MicroRNAs (miRNAs) are short (∼22 nucleotides) non-coding ribonucleic acid (RNA) molecules that negatively regulate the expression of protein-coding genes. Posttranscriptional silencing of target genes by miRNA is initiated by binding to the 3'-untranslated regions of target mRNAs, resulting in specific cleavage and subsequent degradation of the mRNA or by translational repression resulting in ...

A. Distribution of catecholamines in the hypothalamus and effect of norepinephrine on the paraventricular nucleus 1603 B. Hypothalamic catecholamines and normal blood pressure 1603 C. Hypothalamic catecholamines and hypertension 1604 D. Summary 1604 E. Effect on hypothalamic noradrenergic activity of an increase in sodium intake in the young SHR 1604 F. Evidence for an increase in norepinephrin...

Glucagon-like peptide-2 (GLP-2) is secreted from enteroendocrine L-type cells of the gut and also released preproglucagonergic (PPG) neurons in nucleus tractus solitarius (NTS) adjacent medial reticular brain stem. The NTS express GLP-2, send extensive projections to hypothalamus. Recent studies show that intracerebroventricular administration GLP-2 significantly suppresses food intake animals ...

In a previous study, we provided evidence for the presence in hypothalamus and Brockmann bodies (BB) of rainbow trout Oncorhynchus mykiss of sensing systems responding to changes in levels of oleic acid (long-chain fatty acid, LCFA) or octanoic acid (medium-chain fatty acid, MCFA). Since those effects could be attributed to an indirect effect, in the present study, we evaluated in vitro if hypo...

MicroRNAs (miRNAs), a class of small non-coding RNA molecules, play important roles in gene expressions at transcriptional and post-transcriptional stages in mammalian brain. So far, a growing number of porcine miRNAs and their function have been identified, but little is known regarding the porcine developing hypothalamus and pituitary. In the present study, Solexa sequencing analysis showed 1...

The study was made with the help of a chemitrode placed in various areas of the hypothalamus by the stereotaxic technique, for electrical and chemical stimulation (noradrenaline or isoprenaline) before and after microinjection of respective blockers (phenoxybenzamine or practalol). The results indicated the presence of both alpha and beta-adrenoreceptors in the anterior and dorsomedial hypothal...