gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...

obesity is a chronic disease that shows the most serious global health problems .it relates to the body fat .obesity is caused by an imbalance between energy intake and expenditure, this balance is regulated by genetic and environmental interactions. obesity, which is a risk factor for chronic diseases, has become epidemic in the developed countries. resistance to leptin hormone is one of the m...

background: there are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. according to several studies, elevated serum levels of gamma-amino butyric acid (gaba), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. the purpose of this research was to estimate the effects of curcumi...

Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...

background: adiponectin is one of the most important adipocytokines that regulate male and female fertility via adipor1 and adipor2 receptors. recently expression of adiponectin system and its negative regulatory role on hypothalamus-pituitary axis have been confirmed. objectives: no information is available about the expression pattern of adiponectin and its receptors in hypothalamus-pituitary...

introduction: gonadotropin inhibitory hormone (gnih) and agouti-related peptide (agrp) are orexigenic peptides expressed in the arcuate nucleus (arc) of the hypothalamus in the ewe. in addition, effects of gnih and agrp on the regulation of gonadotropin releasing hormone secretion have been shown in some mammals. the objective of the present study was to investigate the coexpression of gnih and...

Obesity is a chronic disease that shows the most serious global health problems .It relates to the body fat .Obesity is caused by an imbalance between energy intake and expenditure, this balance is regulated by genetic and environmental interactions. Obesity, which is a risk factor for chronic diseases, has become epidemic in the developed countries. Resistance to Leptin hormone is one of the m...

The aim of our study was to compare the effects a gold salt (sodium tetrachloroaurate) and nanoparticles colloidal solution on morphofunctional state hypothalamus adrenal glands 6-month-old male rats with obesity, which induced using diet-induced model metabolic disorders. rats, modeled for were divided into three groups that received NaCl solution, 10 days. Rats control group standard diet. Af...