نتایج جستجو برای: ifn
تعداد نتایج: 36626 فیلتر نتایج به سال:
conclusions this study demonstrated the detection of hcv-specific ifn-γ responses in hcv antibody and rna negative individuals, with a tendency for hcv-specific ifn-γ responses to be associated with hcv exposure. the potential role of hcv-specific ifn-γ responses in those who remained hcv rna negative is of value for the development of novel hcv therapeutics. objectives in a cohort of hcv antib...
Background: Lymphadenitis is the most common complication of BCG vaccination in children. Interferon-gamma (IFN-γ) plays a key role in immune response to Mycobacterial infections. In this study, the relationship of serum levels of IFN-γ and its receptor (CD119) to development of Bacillus Calmette Guerin (BCG) axillary lymphadenopathy was investigated. <em...
Background and Purpose: Various abnormalities of the immune system have been demonstrated in patients with chronic kidney disease (CKD). Patients with CKD commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins. Th1 and Th2 cells produce predominantly some cytokine profiles. The aim of the present study was the determi...
T cell proliferation is a standard method to evaluate cellular immune responses against intracellular infectious agents. Recently, intracellular cytokine assay is a valuable procedure for studying of the immune response to various stimuli such as intracellular microbes. The present study was undertaken to assess cell-mediated immune responses in patients with acute ...
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing disease 2019 (COVID-19), resulting in disease, is a worldwide emergency. Because recently it has been found that SARS-CoV dependent on host transcription factors (TF) to express the viral genes, efforts are required understand molecular interplay between virus and response. By bioinformatic analysis, we investi...
Background: We explored the effect of vitamin D receptor gene (VDR) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 μg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels a...
Objective(s) Although, type 2 diabetes is the most frequent type of diabetes, its main cause is yet to be clarified. Several environmental and genetic parameters are believed to be involved in diabetes. It has also been established that cytokines play key roles in pathogenesis of diabetes. Expression of cytokines is different from person to person and in different societies. Several studies sh...
Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) and Leishmanin skin test (LST) between non-healing and healed patients of CL. Patients and ...
Background and purpose: Although Taype 2 diabetes is the most frequent among different types of diabetes, the cause of it is yet to be clarified. Several environmental and genetic factors are said to be involved in diabetes and it has been established that cytokines play key roles in pathogenesis of diabetes. Expression of cytokins is different from person and in defferent societies. Studies ...
Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...
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