نتایج جستجو برای: igd immunoglobulin

تعداد نتایج: 68314  

2017
Leonardo C. T. Bezerra Manuel López-Ibáñez Thomas Stützle

The inverted generational distance (IGD) is a metric for assessing the quality of approximations to the Pareto front obtained by multi-objective optimization algorithms. The IGD has become the most commonly used metric in the context of many-objective problems, i.e., those with more than three objectives. The averaged Hausdorff distance and IGD are variants of the IGD proposed in order to overc...

Journal: :The Journal of Experimental Medicine 1978
S J Black W van der Loo M R Loken L A Herzenberg

B lymphocytes capable of generating primary IgM and IgG plaque-forming cells (PFC) responses to burro erythrocytes have surface IgD, as do primary IgM PFC. IgG memroy cells arising after one injection of antigen are divided into two groups, one of which expresses surface IgD while the other has no detectable membrane IgD. PFC generated from the IgG memory cells lacking surface IgD show a higher...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Ravikumar Balasubramanian Jin-Ho Choi Ludmila Francescatto Jason Willer Edward R Horton Eleni P Asimacopoulos Konstantina M Stankovic Lacey Plummer Cassandra L Buck Richard Quinton Todd D Nebesio Veronica Mericq Paulina M Merino Brian F Meyer Dorota Monies James F Gusella Nada Al Tassan Nicholas Katsanis William F Crowley

Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it is unclear if these alleles are relevant to causality or overall genetic burde...

2013
Arvind Rajpal Pavel Strop Yik Andy Yeung Javier Chaparro-Riggers Jaume Pons

Antibodies, a central part of humoral immunity, have increasingly become a dominant class of biotherapeutics in clinical development and are approved for use in patients. As with any successful endeavor, the history of monoclonal antibody therapeutics benefited from the pioneering work of many, such as Paul Ehrlich who in the late nineteenth century demonstrated that serum components had the ab...

2016
Jin-Tao Zhang Yuan-Wei Yao Marc N. Potenza Cui-Cui Xia Jing Lan Lu Liu Ling-Jiao Wang Ben Liu Shan-Shan Ma Xiao-Yi Fang

Internet gaming disorder (IGD) is characterized by high levels of craving for online gaming and related cues. Since addiction-related cues can evoke increased activation in brain areas involved in motivational and reward processing and may engender gaming behaviors or trigger relapse, ameliorating cue-induced craving may be a promising target for interventions for IGD. This study compared neura...

2016
Jae-A Lim Jun-Young Lee Hee Yeon Jung Bo Kyung Sohn Sam-Wook Choi Yeon Jin Kim Dai-Jin Kim Jung-Seok Choi

Internet gaming disorder (IGD) contributes to poor quality of life (QOL) and cognitive dysfunction and is increasingly recognized as a social problem in various countries. However, no evidence exists to determine whether QOL and cognitive dysfunction stabilize after appropriate management. The present study addressed improvement in QOL and cognitive functioning associated with changes in addict...

Journal: :Journal of Immunology 2023

Abstract There are three extant lineages of mammals: placentals (e.g. humans and mice), marsupials kangaroos opossums), monotremes platypus). Of the lineages, unusually uniformly limited in their immunoglobulin heavy chain (IgH) isotype content. All studied have only one IgM, IgG, IgE, IgA lack IgD. Comparatively, there is a greater complexity IgH isotypes subclasses both monotremes. Marsupials...

2017
Yifan Wang Yanbo Hu Jiaojing Xu Hongli Zhou Xiao Lin Xiaoxia Du Guangheng Dong

Internet gaming disorder (IGD), defined as the persistent use of online games with ignorance of adverse consequences, has increasingly raised widespread public concerns. This study aimed at elucidating the precise mechanisms underlying IGD by comparing intertemporal decision-making process between 18 IGD participants and 21 matched healthy controls (HCs). Both behavioral and fMRI data were reco...

2017
Hoon Jung Koo Doug Hyun Han Sung-Yong Park Jung-Hye Kwon

OBJECTIVE This study aimed to develop and validate a Structured Clinical Interview for Internet Gaming Disorder (SCI-IGD) in adolescents. METHODS First, we generated preliminary items of the SCI-IGD based on the information from the DSM-5 literature reviews and expert consultations. Next, a total of 236 adolescents, from both community and clinical settings, were recruited to evaluate the psy...

2017
Ju-Yu Yen Yi-Chun Yeh Peng-Wei Wang Tai-Ling Liu Yun-Yu Chen Chih-Hung Ko

People diagnosed with Internet gaming disorder (IGD) have been frequently reported to experience depression, anxiety, and hostility. Emotional regulation contributes to these mood symptoms. This study evaluated emotional regulation in subjects with IGD and examined relationships between emotional regulation, depression, anxiety, and hostility in young adults with IGD. We recruited 87 people wit...

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