Recent advances in immunosuppressive drug regimens have changed the outcome after liver transplantation significantly in the last two decades. However, chronic rejection and long-term graft survival remains a major problem. Side effects like drug-induced nephrotoxicity, hypertension, osteoporosis, hyperlipidaemia and neuropathy of some immunosuppressive agents play an essential role in long-ter...

Calcineurin phosphatase plays a crucial role in T cell activation. Dephosphorylation of the nuclear factors of activated T cells (NFATs) by calcineurin is essential for activating cytokine gene expression and, consequently, the immune response. Current immunosuppressive protocols are based mainly on calcineurin inhibitors, cyclosporine A and FK506. Unfortunately, these drugs are associated with...

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

herbal medicines have been used for centuries to treat different illnesses. among more than 20,000 herbal medicines available for humans, a limited number have sufficiently been studied and numerous remained to be investigated for their efficacy in treating human diseases. a number of herbal products are in use for their immunosuppressive effects. this capacity of herbs may have useful applicat...

[This retracts the article on p. 381 in vol. 6, PMID: 26733876.].

The immunosuppressant FK506 binds Plasmodium falciparum FK-506 binding protein 35 (PfFKBP35) and shows anti-malarial activity. To understand molecular mechanism of the drug on the parasite, we have done NMR studies. Here, we report the assignment of FK506-binding domain of PfFKBP35.

Fungal infections of the central nervous system are an uncommon cause of rapid decline in consciousness. We describe the case of central nervous system aspergillosis in a patient on immunosupressants whose clinical course highlights the need for an aggressive approach to diagnosis.

1 Luhby. A. L., et al., Lancet, 1970, 2, 1083. 2 Kotake, Y., and Murakami, E., American Yournal of Clinical Nutrition, 1971, 24, 826. 3 Spellacy, W. N., Buii, W. C., and Birk, S. A., Contraception, 1972, 6, 265. 4 Wynn, V., Lancet, 1975, 1, 561. 5 Coelingh Bennink, H. J. T., and Schreurs, W. H. P., British Medical 7ournal, 1975, 3, 13. 6 Kotake, Y., Inada, T., and Matsumara, Y., Proceedings of ...