نتایج جستجو برای: in vitro dissolution
تعداد نتایج: 16982055 فیلتر نتایج به سال:
A computer-controlled broad-beam ultrasound system is presented that accelerates struvite stone chemolysis in vitro. Hemiacidrin chemolysis was greatly potentiated and was linearly dependent on stone surface area and total ultrasound time. Dissolution also was dependent on citric acid concentration and solution pH, with only minimal dissolution above pH 4.2. Citrate concentrations of 12% provid...
Background: Over the past years, orally disintegrating films (ODFs) have been a suitable alternative to conventional oral dosage forms such as tablets and capsules, especially for patients with dysphagia. ODF is relatively a new dosage form which is prepared using hydrophilic polymers, which rapidly dissolve on tongue or buccal cavity and has other advantages of rapid onset of action and improv...
In vitro dissolution tests for solid oral dosage forms are extremely important to ensure the quality of these products. However, no dissolution test has been reported for finasteride (FNS) in immediate-release capsules. The aims of this work were to optimize a dissolution method for FNS capsules, validate the analytical method, and evaluate three different commercial products. The best in vitro...
We demonstrate the use of modeling and simulation to investigate bioequivalence (BE) concerns raised about generic warfarin products. To test the hypothesis that the loss of isopropyl alcohol and slow dissolution in acidic pH has significant impact on the pharmacokinetics of warfarin sodium tablets, we conducted physiologically based pharmacokinetic absorption modeling and simulation using form...
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