OBJECTIVE To characterize specific mutations within the 21-hydroxylase gene (CYP21-B) using ARMS-PCR assay in patients with congenital adrenal hyperplasia (CAH) and to compare it with that reported in other populations. SUBJECTS AND METHODS Five families, having an index case with CAH diagnosed on the basis of clinical and biochemical findings volunteered to give blood samples for analysis. A...

We researched hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS) as models for studying the pathophysiology of arrhythmias and hypertrophy, and in the process we have had the opportunity to compare local disease profiles with global patterns. We trawled our database entries over the past 20 years to identify all cases of heart muscle and arrhythmic disease. Among these, we separated ...

The recent surge in COVID-19 cases the state of Kerala India has been studied this article. dynamics virus spread, sero-survey results, health index, and herd immunity concept have applied. Kerala, with highest score on index among all states India, is most susceptible to SARS-CoV-2 virus. nearly same number as Germany. “Health Index Theory” established review article first explained well cases...

BACKGROUND This study aimed to evaluate the risk factors associated with developing leprosy among the contacts of newly-diagnosed leprosy patients. METHODOLOGY/PRINCIPAL FINDINGS A total of 6,158 contacts and 1,201 leprosy patients of the cohort who were diagnosed and treated at the Leprosy Laboratory of Fiocruz from 1987 to 2007 were included. The contact variables analyzed were sex; age; ed...

Contact investigations are extremely important components that involved effectiveness of tuberculosis (TB) control programs. Close contacts of multi-drug-resistant tuberculosis (MDR-TB) cases, such as household members, are most likely to become infected because of intense and/or prolonged exposure to index cases. Thus, these contacts are highly recommended to be diagnosed. This study was desig...

BACKGROUND AND PURPOSE Severe ischemic changes are a rare but devastating complication following direct superficial temporal artery to MCA bypass in patients with Moyamoya disease. This study was undertaken to determine whether preoperative MR imaging and/or cerebrovascular reserve assessment by using reference standard stable xenon-enhanced CT could predict such complications. MATERIALS AND ...

PURPOSE Quantitative analyses of proliferation, apoptosis, and angiogenesis, which may be important for the prognosis of retinoblastoma, were performed and possible associations with some well-known clinicopathologic parameters were investigated. METHODS Fifty-three pathology specimens (43 enucleations, 10 exenterations) were evaluated by immunohistochemical methods. The proliferative index w...

UNLABELLED Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in diagnosis of nodular fasciitis, the expression of Ki67 was examined by using immunostaining in 65 nodular fasciitis specimens, 15 desmoid fibromatosis specimens and 20 fibrosarcoma...