Rosmarinic acid is one of the main active components of Coleus blumei and is known to have numerous health benefits. The pharmacological significance of rosmarinic acid and its production through in vitro culture has been the subject of numerous studies. Here, the ability of different tissues to accumulate rosmarinic acid and sustainability in production over long cultivation have been tested. ...

Recent papers have described new bioreactor designs. Most innovations addressed either oxygen transfer, shear induced by stirring, control of water activity in organic phase systems or waste biotreatment. Innovations made during the past year were reported in mainly three areas: bioreactor designs for increases in oxygen transfer and decreases in shear stress; bioreactors for two-phase reaction...

Background: Nowadays, the optimization of the culture conditions in bioreactors is considered as an approach to produce secondary metabolites such as thebaine. Thebaine is the dominant alkaloid in Iranian poppy that is used as a precursor for the synthesis of analgesic compounds. Objective: Optimization of culture conditions of Papaver bracteatum adventitious roots in bioreactor for the scale...

In vitro arterial flow bioreactor systems have been used in tissue engineering as models to investigate the response of endothelial cells to shear. However, the degree to which such models can reproduce physiological flow has not been quantified. Furthermore, previous works have assumed a Poiseuille flow profile for the calculation of wall shear stresses (WSS) experienced by the endothelial lay...

The hydrodynamics of an internal-loop airlift reactor was numerically and experimentally characterized. gas holdup, liquid velocity, shear rate, flow pattern volumetric oxygen transfer coefficient (kLa) were evaluated as a function the air velocity medium rheology. Tap water CMC solutions used Newtonian non-Newtonian fluids, respectively. standard  model employed for modeling turbulence, uns...

Identification based PID tuning is studied. The proposed approach consists of the identification of linear or nonlinear process model and model based control design. The identification test can be performed in both open loop and closed-loop. The so-called ASYM method is used to solve the identification problem. The method identifies a low order process model with a quantification of model error...