Pansclerotic morphea(PSM) is an extremely rare, devastating disease characterized by extensive soft tissue fibrosis, secondary contractions, and eventual death. The pathogenesis of PSM unknown, aggressive immunosuppressive treatments rarely slow progression. Here, we sought to comprehensively characterize the cellular molecular events underlying identify novel therapeutic targets. We performed ...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

t/nk cell proliferative ebv associated disease is a rare one which is more common in eastern asian countries. ebv is originally associated with b cells, and ebv associated t cell lymphoma is so rare. hence we decided to describe a patient treated with misleading diagnoses such as tb and sarcoidosis for almost two years. the liver was biopsied after admission in this center, and gastric and colo...

The development of gastroenteritis caused by non-typhoidal Salmonella (NTS) is mediated the action effectors that belong to Type three secretory systems (T3SS) enterica. These are expressed pathogenicity islands 1 and 2 located in genome. T3SS-1 provide invasion salmonella into host cell, take part inflammatory diarrhea some may act as a predisposing factor oncogenesis leading colorectal cancer...

Traumatic brain injury (TBI) is defined as an external mechanical injury to the brain. Neuroinflammation plays a vital role in the pathophysiology of TBI. Microglia and astrocytes play a central role in the initiation and regulation of inflammation. Numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ROS) and nitric oxide (NO) released by microglia. In ...

programmed cell death is a highly regulated form of cell death, mostly distinguished by the activation of a family of cystein-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. several recent studies have addressed the role of programmed cell death in inflammatory and chronic pain states. casp...