The efficacy and toxicity of ganciclovir given by intravenous or intravenous plus intravitreal injection were studied in nine patients with cytomegalovirus (CMV) retinitis; seven with AIDS and two with drug induced immunodeficiency. Five patients had retinitis with macular involvement in six sighted eyes; six patients had only peripheral retinitis in seven eyes. In two patients (two eyes) with ...

Two cases of intravenous injection of elemental mercury are described in this report. One patient succumbed and the other remains asymptomatic two years after the surgical removal of all the injected mercury. Management of intravenous injection of elemental mercury (intended to be an aphrodisiac in these two cases) is discussed here and the need for surgical removal of all accessible mercury ha...

We determined islet amyloid polypeptide (IAPP) response in plasma to oral and intravenous glucose administration and intravenous insulin injection in nondiabetic subjects. Moreover, we studied the effect of somatostatin analogue SMS 201-995 on glucose-induced IAPP secretion in nondiabetic subjects. Plasma IAPP concentration was determined by radioimmunoassay. Oral administration of 75 g glucose...

A 27-year-old woman developed dyspnea and wheezing within 10 min after eating a piece of raspberry walnut cake, was successfully treated with intravenous corticosteroid intramuscular injection adrenaline. An open oral provocation test demonstrated immediate respiratory hypersensitivity reaction.

Numerous studies have demonstrated promising application of single-walled carbon nanotubes (SWNTs) in drug delivery, diagnosis, and targeted therapy. However, the adverse health effects resulting from intravenous injection of SWNTs are not completely understood. Studies have shown that levels of "pristine" or carboxylated carbon nanotubes are very high in mouse lungs after intravenous injection...

6th June, 1925.?No response to quinine (grs. 5 t.d.s.) given from 2nd June, 1925, 9-30 p.m. Temperature 106?F. Intravenous injection of quinine bihydrochloride (grs. 3). 7th June, 1925.?8 a.;m. Temperature 98.6?F. Intravenous injection of quinine bihydrochloride (grs. 2i). Urine now distinctly "milky," showed marked chyluria and the microscope revealed a large number of microfilariae. The quini...

In an attempt to determine whether, following intravenous injection of hypertonic solutions of sodium chloride, an increased amount of this salt could be detected in the cerebra-spinal fluid, it was noted that within a short time after the intravenous injection, cerebra-spinal fluid could not be obtained when the subarachnoid space was entered. This observation led at once to the attachment of ...

This phase I study compared pharmacokinetics and pharmacodynamics, and assessed safety and efficacy of intravenous and subcutaneous administration of bortezomib. Relapsed or refractory multiple myeloma patients were randomized to receive bortezomib by standard intravenous bolus (n=12) or subcutaneous injection (n=12) at the recommended dose and schedule (1.3 mg/m2, days 1, 4, 8, 11; eight 21-da...