Introduction Joint space narrowing (JSN) is a measureable outcome of the tissue degeneration caused by the inflammatory process of the synovium in arthritis. JSN is usually assessed by conventional radiography. Ultrasonographic measurements of joint cartilage thickness in large and small joints have been validated in a study of healthy children and recently, measurements of distal femoral carti...

OBJECTIVE Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process. METHODS Genome wide gene expression was determined in paired samples of OA affected and preserved cartilage of the same joint using microarray analysis for 33 patients of the RAAK study. Results were replicated in independent samples by RT...

PURPOSE To histologically evaluate the quality of articular cartilage regeneration from the medial compartment after arthroscopic subchondral drilling followed by postoperative intra-articular injections of autologous peripheral blood stem cells (PBSCs) and hyaluronic acid with concomitant medial open-wedge high tibial osteotomy (HTO) in patients with varus deformity of the knee joint. METHOD...

conclusions it can be concluded that due to some bioactive and nutrient factors, mscs secretions could be used for recovery of oa as well as prevention of articular cartilage matrix degeneration, using a high dose of cell secretions. results the results revealed a decrease of proteoglycan content in the superficial and intermediate zones and presence of surface fibrillation. therefore, oa induc...

OBJECTIVE The purpose of this study was to perform a quantitative evaluation of the effect of static magnetic field orientation on cartilage transverse (T2) relaxation time in the intact living joint and to determine the magnitude of the magic angle effect on in vivo femoral cartilage. MATERIALS AND METHODS Quantitative T2 maps of the femoral-tibial joint were obtained in eight asymptomatic m...

OBJECTIVE Joint health is affected by local and systemic hormones. It is well accepted that systemic factors regulate the metabolism of joint tissues, and that substantial cross-talk between tissues actively contributes to homeostasis. In the current review, we try to define a subtype of osteoarthritis (OA), metabolic OA, which is dependent on an unhealthy phenotype. METHODS Peer-reviewed res...

Structural changes of bone and cartilage are a hallmark of inflammatory joint diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Despite certain similarities - in particular, inflammation as the driving force for structural changes - the three major inflammatory joint diseases show considerably different pathologies. Whereas RA primarily resu...

Damage and degeneration of articular joints is a major healthcare concern, due to the association of joint disease with ageing, the current strong demographic changes in the proportion of elderly in the population, and the increased incidence of trauma in a sports-active younger population. These joints are biomechanical organs that transmit load between bones in our skeleton, and the articular...

The acute childhood diseases haematogenous staphylococcal osteomyelitis and septic arthritis were studied concurrently using avian models which closely resemble the human diseases. Ultrastructural studies during the initial stages of bone and joint infection showed that adherence of bacteria to cartilage, bacterial proliferation, cartilage destruction and subsequent bacterial spread along the v...