Interactions between different cytokines, extracellular matrix components, and various cell types inside the bone marrow microenvironment are believed to play important roles in the regulation of hematopoiesis. We observed that both interleukin-l (IL-l) and 12-0-tetradecanoylphorbol-13-acetate (TPA) can stimulate the expression of IL-l1 and granulocyte-macrophage colony-stimulating factor (GM-...

Both vibrationally and rotationally resolved spectra of the S, + So transition in jet-cooled triphenylamine (TPA) around 340320 nm are reported. Medium resolutton spectra (0.5-l .O cm-’ resolution) are recorded using ( 1 + 1 )-resonance enhanced multi photon iomzation (REMPI) with mass selective time-of-flight (TOF) detection in a pulsed molecular beam apparatus. The origin ofthe S,+ So transit...

Application of the potent tumor promoter, 12-O-tetra decanoylphonbol-13-acetate (TPA), to mouse skin leads to a more than 200-fold increase in epidermal ornithine decan boxylase (EC 4.1.1.17) activity, a phenotypic change pro posed to be essential for skin tumor promotion. The come lation between TPA-induced omnithine decarboxylase activ ity and skin tumor promotion received additional support ...

background: thrombolytic therapy is the only approved treatment for acute cerebral ischemia. the hemorrhagic transformation is the greatest complication of this treatment, which may occur after recanalization of occluded artery. the aim of this study was to determine factors associated with clinical improvement and worsening in patients with acute ischemic stroke treated with intravenous thromb...

Application of the potent tumor promoter, 12-O-tetra decanoylphonbol-13-acetate (TPA), to mouse skin leads to a more than 200-fold increase in epidermal ornithine decan boxylase (EC 4.1.1.17) activity, a phenotypic change pro posed to be essential for skin tumor promotion. The come lation between TPA-induced omnithine decarboxylase activ ity and skin tumor promotion received additional support ...

BACKGROUND With continued increase in the use of mechanical circulatory support, the incidence of device thrombus remains a challenge. This study is a retrospective analysis of data at a single center to assess the safety and efficacy of thrombolytic use in durable mechanical assist devices. METHODS Data was analyzed retrospectively from 154 patients who underwent left ventricular assist devi...

The abundant proteolytic plasminogen (Plg)/plasmin system is important in several physiological functions in mammals and also engaged by a number of pathogenic microbial species to increase tissue invasiveness or to obtain nutrients. This paper reports that a commensal bacterium, Lactobacillus crispatus, interacts with the Plg system. Strain ST1 of L. crispatus enhanced activation of human Plg ...

A novel sulfur-terminal Cd(II) complex, CdS(2)L (L = N-hexyl-3-{2-[4-(2,2':6',2''-terpyridin-4'-yl)phenyl]ethenyl}-carbazole), was successfully synthesized from CdS nanocrystals and the organic chromophores (L), which was confirmed by single-crystal X-ray diffraction analysis. Its photophysical properties have been investigated both experimentally and theoretically. The novel hybrid nanoparticl...

The present study was aimed to evaluate the protective effects of Hydroethanolic Murraya koenigii leaves extract (HEMKLE) against DMBA/TPA-induced angiogenesis, hepatotoxicity and renal toxicity during skin carcinogenesis in mice. For study, male LACA mice were divided into four groups: Group I (C), II (DMBA/TPA), III (HEMKLE), IV (HEMKLE+DMBA/TPA). 7, 12-dimethylbenz(a) anthracene (DMBA), 12-O...