= Abstract = Review of 8 cases of heterotopic lacrimal gland tissue in epibulbar conjunctival region disclosed frequent mixture of pilosebaceous structure, adipose tissue, smooth muscle. etc. The term complex choristoma appears appropriate to designate a mixture of this variety, although each element can be predominant in a single lesion. Complex choristoma containing lacrimal gland was commonl...

In this project, we strived to develop a decellularized human cornea to use as a scaffold for reconstructing the corneal epithelium and anterior stroma. Human cadaver corneas were decellularized by five different methods, including detergent- and nondetergent-based approaches. The success of each method on the removal of cells from the cornea was investigated. The structural integrity of decell...

PURPOSE To characterize changes in corneal collagen arrangement during mouse postnatal development. METHODS Small-angle X-ray scatter patterns were gathered from the centers of 32 excised mice corneas aged between postnatal days 10 (before eye opening) and 28 (onset of sexual maturity). These were analyzed to produce measurements of the average separation distance between corneal collagen fib...

say 2 weeks later, the ulcer wouild inflame again, and we would be compelled to cover the cornea again, as has happened. Even 2-3 months later we have seen a weak relapse with a small hypopyon for a few days. As far as our observations go, the interval of at least 6 months has to be kept. It is surprising, how willingly our patients wait, till the set term is over. The re-opening is a simple pr...

PURPOSE Heterozygous defects in the highly conserved PAX6 homeobox gene are associated with aniridia, an inherited human disorder affecting several ocular structures, including the adult cornea. This work establishes the pattern of Pax-6 gene expression in the surface epithelia of the late embryonic and adult eye. METHODS Chick embryo sections and wholemounts, as well as adult mouse and monke...

PURPOSE In this work, we decellularized whole porcine corneas including the sclerocorneal limbus (SCL) and we evaluated regional differences in order to identify an efficient method to decellularize whole corneas for future clinical use. METHODS We analyzed the efficiency of four decellularization protocols based on benzalkonium chloride (BAK), Igepal, sodium dodecyl sulfate (SDS), and Triton...

BACKGROUND Transplantology is a quickly developing field of ophthalmology. It currently is able to treat many inherited, degenerative, inflammatory, traumatic, and cancerous diseases. This review outlines recent concepts and methods of treating ocular diseases with tissue and cell grafts. Ocular transplants related to the anterior part of the eye, including the conjunctiva and the cornea, are r...

THE migration of an intra-ocular foreign body, with or without its subsequent spontaneous extrusion from the eye, has been reported several times in the literature, though in few instances in any detail. It was first described by de Castelnau (1842), who recorded how a man sustained an injury to his right eye, followed, 3j years later, by the spontaneous extrusion through the cornea of a partic...

Causes of Melanosis other than Chlorpromazine THE pathological deposition of melanin is rarely seen in the tissues of the eye. Normally, small collections of melanin are sometimes seen in the eyes of Caucasians where the ciliary vessels pierce the sclera near the limbus. Larger collections of melanocytes form a benign naevus which may invade the cornea, or there may be multiple collections of m...

PURPOSE To develop an animal model for simultaneously eliciting corneal angiogenesis and retinal gliosis that will enable the assessment of inhibitor efficacy on these two pathological processes in separate anatomic sites of the ocular globe. METHODS Four to six week-old mice in a C57BL/6J background were anesthetized and 0.15 N NaOH was applied to the cornea, followed by mechanical scraping ...