BACKGROUND Roux-en-Y gastric bypass (RYGB) improves the pathophysiology that contributes to obesity-related nonalcoholic steatohepatitis (NASH). Whether obesity-related fibrosis improves is unclear. We hypothesized that RYGB reverses NASH and fibrosis, and indocyanine green (ICG) clearance provides a sensitive measure for detecting asymptomatic fatty liver disease. METHODS One hundred six obe...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

Fish oil contains eicosapentaenoic acid (E.P.A.) and docosahexaenoic (D.H.A.) which are beneficial for heart health, controlling blood glucose, reducing atherosclerosis, lowering the risk of cancer. This study aims to determine effect commercial feed supplemented with cod liver on glucose levels pancreatic histology male rabbits. Twenty rabbits were divided into four groups, namely 3% (P1), 4.5...

Congenital generalized lipodystrophy (CGL, Berardinelli-Seip syndrome) is a rare autosomal recessive disorder with a clinical presentation of paucity of adipose tissue, muscular hypertrophy, organomegaly, and insulin-resistant diabetes. A 4-month-old Taiwanese female infant had hepatosplenomegaly and low body weight gain despite a voracious appetite. Hypermetabolism, hyperhidrosis, loss of subc...

The liver is the third-most-common site for intra-abdominal malignancy in children, follow‐ ing adrenal neuroblastoma and wilms tumor. Although the overall incidence of childhood cancer has been slowly increasing since 1975, cancer in children and adolescents is still rare, the incidence of primary malignant liver tumors per year is 1-1.5 per million children in the United States [1, 2, 3, 4]. ...

Serum glutamate dehydrogenase (EC 1.4.1.3.) activity was measured in 73 hospital patients who had a history of chronic alcohol abuse and who all had a liver biopsy performed. High levels of serum GDH activity occurred in those patients with recent excess alcohol consumption independently of the underlying liver histology, and did not discriminate between those patients with and those without al...

Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide, particularly in South and South East Asia. Unfortunately due to lack of appropriate facilities and awareness only limited information is available about its early diagnosis. Aim of the present study was to determine the efficacy of p53 by immunohistochemistry and Argyrophilicnucleolar organizer regions (AgNORs) in d...