This protocol describes the 5-choice serial reaction time task, which is an operant based task used to study attention and impulse control in rodents. Test day challenges, modifications to the standard task, can be used to systematically tax the neural systems controlling either attention or impulse control. Importantly, these challenges have consistent effects on behavior across laboratories i...

Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior deficiency on vulnerability to inflammation-induced acute cognitive dysfunction unclear. Here we assessed whether noradrenergic depletion, female mice, impacted upon inflammation, locomotor activity working memory directly after systemic immune challenge bacterial lipopolysacchar...

The recovery of treadmill locomotion of eight adult cats, subjected to chronic ventral and ventrolateral spinal lesions at low thoracic levels (T11 or T13), preserving at least one dorsolateral funiculus and the dorsal columns, was documented daily using electromyographic (EMG) and kinematic methods. The data show that all cats eventually recovered quadrupedal voluntary locomotion despite exten...

To the Editor, The Indian Medical Gazette Sir,?The following notes of a case may be of interest to your readers, illustrating as it does the danger of unqualified practitioners;? B. S., a Hindu male, aged 45 years, came to me with syphilitic iritis. He could not afford a full course of treatment so consulted a Baid (an hereditary ophthalmic practitioner). He applied a mixture of lime, washingso...

Objective- Locomotor disorders are prevalent health problems in dairy herds that negatively affect milk production, reproduction performance and animal welfare. The ultimate cost of locomotor disorders in dairy cattle is substantially greater than treatment costs alone. As limited information is available on incidence of feet and leg disorders in Iran, the objective of this study was to determi...

Suprachiasmatic nuclei (SCN)-lesioned rats, showing a locomotor activity rhythm with a circadian period by chronic methamphetamine treatment, were subjected to the periodic food restriction (RF) of 4 h per every 27 h and 24 h. All rats were phase set by the feeding schedule of both 24-h and 27-h periods. Phase angle differences between the activity onset and food presentation were more positive...

Sensory inputs from muscle, cutaneous, and joint afferents project to the spinal cord, where they are able to affect ongoing locomotor activity. Activation of sensory input can initiate or prolong bouts of locomotor activity depending on the identity of the sensory afferent activated and the timing of the activation within the locomotor cycle. However, the mechanisms by which afferent activity ...

Down syndrome (DS) results from one extra copy of human chromosome 21 and leads to several alterations including intellectual disabilities and locomotor defects. The transchromosomic Tc1 mouse model carrying an extra freely-segregating copy of human chromosome 21 was developed to better characterize the relation between genotype and phenotype in DS. The Tc1 mouse exhibits several locomotor and ...

Healthy aging impairs the ability to adapt movements to novel situations and to switch choices according to the context in cognitive tasks, indicating resistance to changes in motor and cognitive behaviors. Here we examined if this lack of "flexibility" in old subjects observed in motor and cognitive domains were related. To this end, we evaluated subjects' performance in a motor task that requ...