The study was devised to prepare berberine nanoparticles by anti-solvent precipitation method and were assessed for their hepatoprotective effect in Male Sprague-Dawley rats against carbon tetrachloride. pharmacokinetic parameters of the prepared evaluated rabbits. Histopathological studies blood biochemical analyses carried out evaluate role both forms experimental animals. Substantial improve...

SEX-DEPENDENT ROLE OF INTERLEUKIN-1 SIGNALING IN EMOTIONAL AND COGNITIVE BEHAVIORS IN MICE: PHENOTYPING MALE AND FEMALE 1L1-R1 NULL MUTANT MICE by Jennifer A. Johnson Adviser: Adjunct Associate Professor Susan D. Croll IL1-­‐R1 null mutant mice (IL1-­‐R1 KO) have reduced signaling in the interleukin-­‐1 (IL-­‐1) pathway, making them a convenient ...

Studies show that restraint stress influences male reproductive system. The main purpose of this study was to study the effects of restraint stress on serum LH, FSH or testosterone level and testes tissue in rats. Methods: Male Wistar rats were randomly divided into control, acutely or chronically immobilized animals of 5 in each group. In chronically or acutely immobilized groups, animals were...

s:2011:"Background: Imidacloprid (IMD) is a systemic insecticide which acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids which act on the central nervous system of insects. According to previous studies, IMD is rated as "moderately toxic" on an acute oral basis to mammals and according to United States Environmental Protection Agency this compound is cla...

A bioassay of a solution of 30 percent b-nitrostyrene and 70 percent styrene for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. The solution of the two test materials in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The high and low dosages utilized in the study were, respectively, 300 a...

clinical asthma and airway responsiveness appear to be less severe when diabetes is superimposed. the aim of the present study was to determine the possible role of nitric oxide (no) in the airway reactivity under diabetic and diabetic-allergic conditions. twenty-five male guinea-pigs were divided into five groups of five each as follows: diabetic, antigen sensitized, diabetic- antigen sensitiz...

Androgens have been postulated to be important modulators of adipose tissue metabolism and fat cell function. In the present study, we investigated the response of male and female mice retroperitoneal adipose tissue to the nonaromatizable androgen dihydrotestosterone (DHT). Adipose tissue samples were obtained in gonadectomized animals treated with vehicle (control group), or injected with 0.1 ...

In Drosophila, the sex of germ cells is determined by cell-autonomous and inductive signals. XY germ cells autonomously enter spermatogenesis when developing in a female host. In contrast, XX germ cells non-autonomously become spermatogenic when developing in a male host. In first instar larvae with two X chromosomes, XX germ cells enter the female or the male pathway depending on the presence ...

A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at age 4-6 months. However, this neonatal model requires optimization and a detailed study into metabolic hormonal parameters adult animals. The aim work was these male rats deprived breast milk 19-21 days, which achieved by treating lactating females with bromocriptine. Adult showed an increased b...