When young female A X C rats were given 9.6 rads of 0.43-MeV neutrons, 32 of 33 survived a 50-week follow-up period, 2 rats developed a total of 3 mammary adenocarcinomas, and 3 rats developed a total of 4 mammary fibroadenomas. For 25 rats implanted with a 20-mg pellet containing 5 mg diethylstilbestrol and 15 mg cholesterol, average survival was 284 days; 22 rats developed a total of 182 mamm...

One topical application of 0.02 mmole of /V-hydroxy-2fluorenylacetamide to the left thoracic glands of adult female Sprague-Dawley rats gave a 70% tumor incidence at the site. The tumors appeared 3 to 6 months after the application and were mammary adenocarcinomas. In contrast, the tumor incidence after application of N-2fluorenylacetamide was 30%, the latent period was 8 to 11 months, and the ...

One topical application of 0.02 mmole of /V-hydroxy-2fluorenylacetamide to the left thoracic glands of adult female Sprague-Dawley rats gave a 70% tumor incidence at the site. The tumors appeared 3 to 6 months after the application and were mammary adenocarcinomas. In contrast, the tumor incidence after application of N-2fluorenylacetamide was 30%, the latent period was 8 to 11 months, and the ...

To investigate the role of membrane-type matrix metalloproteinase-1 (MT1-MMP) in mammary gland development and tumorigenesis, transgenic mice overexpressing MT1-MMP in mammary gland under the control of the mouse mammary tumor virus long terminal repeat-promoter were generated. The mouse mammary tumor virus/MT1-MMP transgenic mice displayed abnormalities in 82% of female mammary glands. The abn...

Mammary glands were successfully transplanted from randombred Sprague-Dawley rats to recipients, irrespective of whether the transplants were autografts or homografts. Homologous transplantation of mammary glands was successful in both littermates and nonlitterJDates. Surviving grafts had the histological appearance of nonnalmammary glands and functioned like the nOrJDal mammary glands of the r...

The Ron receptor tyrosine kinase (macrophage stimulating 1 receptor) is overexpressed in approximately 50% of human breast cancers. Transgenic mice overexpressing Ron in the mammary epithelium [mouse mammary tumor virus driven (MMTV)-Ron expressing mice] develop mammary tumors that exhibit up-regulation of β-catenin and β-catenin target genes. β-Catenin has been shown to be a mediator of mammar...

The four quarters of bovine mammary glands are completely separated and two quarters on each side (right or left) are connected to ipsi lateral supra mammary lymph nodes. It is not clear whether cells infused into the cistern of the mammary gland are capable of migrating to lymph nodes or the general circulation. To examine cell migration, a prescapular lymph node was removed from each of two l...

The administration of large doses of estrogen to young male mice was followed by less extensive mammary gland growth than when small amounts of estrogens were given". The areas occupied by the mammary glands of the mice given large doses were often but little larger than the glands of untreated controls, but unlike the controls their mammary glands, although very small, had a few alveoli on the...

Spontaneous mammary tumours frequently appear in women, dogs, cats and rodents. Their origin is known only in mice, where the mouse mammary tumour virus (MMTV) gives rise to them. Sexual hormones are involved in the development of mammary tumours; in women, oestrogen is important and most studied whereas progesterone is more important in the dog, where spaying at early age prevents mammary tumo...

Vitásek R. , H. Dendisová: Treatment of Feline Mammary Fibroepithelial Hyperplasia Following a Single Injection of Proligestone. Acta Vet. Brno 2006, 75: 295-297. A case of fibroepithelial hyperplasia of the mammary gland in the cat is reported. A seven-monthold female cat was presented for diffuse enlargement of all of the mammary glands. The cat was treated with proligestone (Covinan®) for th...