BACKGROUND Diaphragmatic dysfunction found in the patients with acute lung injury required prolonged mechanical ventilation. Mechanical ventilation can induce production of inflammatory cytokines and excess deposition of extracellular matrix proteins via up-regulation of transforming growth factor (TGF)-β1. Lumican is known to participate in TGF-β1 signaling during wound healing. The mechanisms...

Mechanical ventilation is an important life support treatment of critically ill patients, and air pressure dynamics of human lung affect ventilation treatment effects. In this paper, in order to obtain the influences of seven key parameters of mechanical ventilation system on the pressure dynamics of human lung, firstly, mechanical ventilation system was considered as a pure pneumatic system, a...

IMPORTANCE Extubation failure is common in extremely preterm infants. The current paucity of data on the adverse long-term respiratory outcomes associated with reinitiation of mechanical ventilation prevents assessment of the risks and benefits of a trial of extubation in this population. OBJECTIVE To evaluate whether exposure to multiple courses of mechanical ventilation increases the risk o...

The aim of this study was to explore the ethical challenges in home mechanical ventilation based on a secondary analysis of qualitative empirical data. The data included perceptions of healthcare professionals in hospitals and community health services and family members of children and adults using home mechanical ventilation. The findings show that a number of ethical challenges, or dilemmas,...

results there were 80 successful and 44 unsuccessful as well as 72 successful and 8 unsuccessful weaning cases in the first and second phase of the study, respectively. the area under the roc curves for iwi was 0.967, with standard error of 0.020, 95% confidence interval of 0.899 to 0.993 and significance level of p = 0.001, se = 94.59, sp = 66.67, ppv = 97.22, npv = 50, da = 92.5 and likelihoo...

background critically ill patients under mechanical ventilation require frequent suctioning of airway secretion. closed suction permits suctioning without disconnection from ventilator; so it might decrease hypoxemia and infection rate. objectives this study aimed to evaluate the effect of closed tracheal suction system (ctss) versus open tracheal suction system (otss). patients and methods thi...

BACKGROUND Mucolytic agents, such as nebulized hypertonic saline, may improve airway clearance and shorten the duration of mechanical ventilation, but prospective blinded studies in children undergoing mechanical ventilation are lacking. METHODS Children <18 y old who had been intubated for <12 h and had an expected duration of mechanical ventilation of >48 additional h were prophylactically ...

OBJECTIVES This research aimed to evaluate the repercussions of specific chest physiotherapy procedures in mean airway resistance and in dynamic compliance in preterm infants in mechanical ventilation. METHODS Eighteen preterm infants in conventional mechanical ventilation were submitted to one session of chest physiotherapy (manual chest compression during expiration + intermittent aspiratio...

STUDY OBJECTIVE To report the outcome of patients with autologous peripheral blood stem cell transplantation (PBSCT) receiving mechanical ventilation. DESIGN Retrospective observational study. SETTING Active hematopoietic stem cell transplantation center and a university hospital medical ICU. PATIENTS Patients with autologous PBSCT receiving mechanical ventilation. METHOD A review of th...

Background and Objectives: Suction is a necessary and common method which aids in the release of secretion from the respiratory system for the patients who have undergone mechanical ventilation. One of the most common complications of suction is hypoxemia which causes dysrhythmia and death. The purpose of this study was to determine the effects of open and closed-endotracheal suction on cardiov...