More than 50 years ago, Victor Herbert first described the concept that defective nucleoprotein synthesis, attributable to various causes, results in the development of megaloblastic anemia.1 Megaloblastic anemia is characterized by the presence of a hypercellular marrow with large, abnormal hematopoietic progenitor cells with a characteristic finely stippled, lacy nuclear chromatin pattern. Th...

The association of megaloblastic vitamin B12 deficiency anemia and essential thrombocythemia is very rarely described in the literature. We reported a case 65-year-old patient with an isolated chronic anemic syndrome secondary to treated therapy by injection. evolution was marked three months after treatment ischemic cerebrovascular accident thrombocytosis. Additional investigations confirmed thr...

By R. J. CALVERT, E. HUnwoilTil AND A. L. MACBEAN I HE OCCASIONAL DEVELOPMENT of megaloblastic anemia during the administration for months or years of certain anticonvubsant drumgs ( phenytom sodium and/or primidone, with or withoumt phenobarbital ) has been reviewed by Gydell#{176} and Newman and Sumner.11 Ouir report concerns an epileptic patient who presented as a gynecologic emergency with ...

The introduction of reliable techniques for the measurement of serum levels of vitamin B12 and folate has meant that megaloblastic anaemias can be more readily classified as being due to deficiency of one or occasionally both of these substances. The excretion of formiminoglutamic acid (figlu) in the urine of patients with folic-acid deficiency has further aided this differentiation. However, u...