MegalobJastic Anemia in Pregnancy Megaloblastic Anemia is one of The Rather Common Diseases of Pregnant Women Caused by Folic acid Defi­ciency The Disease Might Be Hazardous To affected Mo­thers and also Could be Fatal for foetus too.  Megaloblastic Pregnant Women Will have Signs and Symptoms of This Disease mostly after 29th. Week of pregnancy.  Adequate amount of Folate Will prevent Compli...

Combined megaloblastic anemia with thalassemia is easily masked because of the loss of macrocytosis. We performed a retrospective study to compare the major parameters in 4 groups of subjects in order to show the characteristics of patients with megaloblastic anemia and thalassemia. Group A comprised 9 patients with megaloblastic anemia and tha-lassemia, group B comprised 10 patients with uncom...

We have described a case of chronic arsenic intoxication associated with pancytopenia and megaloblastic erythropoiesis. The patient had the typical laboratory manifestations of effective erythorpoiesis due to a megaloblastic process, including macroovalocytes, mild pancytopenia, low reticulocyte index, increased marrow cellularity with erythroid hyperplasia, and morphologic evidence of megalobl...

BACKGROUND Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis. AIMS To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia. SETTINGS AND DESIGN The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations...

CBC data for diagnosing classical megaloblastic anemia. Other features such as pancytopenia, elevated RDW, serum LDH and indirect bilirubin, as well as LDH1>LDH2 are also helpful. If a patient has a normal or low MCV, megaloblastic anemia is not usually the first consideration, which might lead to a missed diagnosis or delay in giving treatment. The present study shows that the combined disease...

I enjoyed the article by 1. Eivazi Ziai, et al. concerning "Use of myeloperoxidase index as a suitable tool to monitor response to therapy in patients with megaloblastic anemia" that was published in the last issue of the Medical Journal ofIslamic Republic of Iran. I I would like to make some points regarding this study. A. The authors mentioned that in primary evaluation of 50 anemic pa...

thiamine responsive megaloblastic anemia in didmoa (wolfram) syndrome has an autosomal- recessive mode of inheritance . megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (di), diabetes mellitus (dm) ,optic atrophy (oa) and deafness (d). neutropenia and thrombocytopenia are also present. we report a 7 month old girl with congenital macrocytic anemia a rare clinic...

A distinction must be drawn between megaloblastic and macrocytic anaemias. Not all macrocytic anaemias are megaloblastic and not all megaloblastic anaemias are macrocytic. The term macrocytosis refers to the size of red blood cells in the peripheral blood. The mean cell volume of packed red blood cells (haematocrit) may be greater than normal, or the diameters of a proportion of red blood cells...

We report the observation of a high neutrophil myeloperoxidase activity (MPXI) in patients with megaloblastic anemia. MPXI is rapidly measured as part of an automated complete blood count (Technicon H*1, Technicon Instruments Corp, Tarrytown NY). We describe the range of MPXI levels in healthy and patient populations and in 10 cases of megaloblastic anemia, including five having elevated mean c...

To elucidate the biochemical basis of megaloblastic hematopoiesis, the cellular content and metabolism of deoxyribonucleoside triphosphates (dNTPs) were investigated using the bone marrow cells from nine patients with untreated vitamin B12 deficiency and one with folic acid deficiency. The marked imbalance among four dNTPs was noted in all patients. dTTP was invariably elevated rather than depr...