in vitro expansion of mesenchymal stem cell (mscs) into large number is necessary for their application in cell-based treatment of articular cartilage defects. on the other hand, some studies have indicated that bio (6-bromoindirubin-3-oxime) possesses mitogenic effects on cell culture. the objective of the present study was to examine the effect of bio on in vitro expansion and chondrogenic di...

the aim of this study was to investigate the interactions between rat intestine decellularized scaffold and human adipose derived mesenchymal stem cells. rat large intestine was dissected in fragments and decellularized by physicochemical methods. the scaffolds were loaded by human adipose derived mesenchymal stem cells expressing green fluorescent protein. microscopic sections were prepared fr...

introduction: recognition of human leukocyte antigens (hla) is of importance for hematopoietic stem cell transplantation. any hla-mismatches between the donor and recipient can cause graft rejection or other complications. in hla-typing experiments, usage of hla-known reference cells accompany with hla-unknown samples is obligatory. some international centers represent these cells with high exp...

background: myocardial infarction is the main cause of death worldwide. angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. this study focused on improving myocardial function using endothelial cells (ecs) and mesenchymal stem cells (mscs) in a sheep animal model. methods: acute myocardia...

introduction: although, the effect of direct intra-articular injection of bone marrow stem cells (bmscs) on the repair of articular cartilage and the effect of elaeagnus angustifolia extract on pain relief in patients with osteoarthritis have been investigated, no studies has been conducted to compare the effects of these two therapeutic methods on the mechanical properties of articular cartila...

introduction: iiron oxide nanoparticles (io np) have an increasing number of biomedical applications. to date, the potential cytotoxicity of these particles remains an issue of debate. little is known about the cellular interaction or toxic effects of io np on differentiation of stem cells. the aim of the present study was to investigate the possible toxic role of different doses of io np in di...

the wharton’s jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (mscs) which can be therapeutically applied in degenerative diseases. in this study, we investigated the immunomodulatory effect of umbilical cord derived- mesenchymal stem  cells (uc-mscs) and  bone  marrow-derived-mesenchymal stem  cells (bm-mscs) on differentiation, maturation, and endocytosis of m...

Experimentally, peripheral nerve repair can be enhanced by Schwann cell transplantation but the clinical application is limited by donor site morbidity and the inability to generate a sufficient number of cells quickly. We have investigated whether adult stem cells, isolated from adipose tissue, can be differentiated into functional Schwann cells. Rat visceral fat was enzymatically digested to ...

Purpose: The hallmark of neurofibromatosis type 1 (NF1) is the onset of dermal or plexiform neurofibromas,mainly composedof Schwann cells. Plexiformneurofibromas can transform intomalignant peripheral nerve sheath tumors (MPNST) that are resistant to therapies. Experimental Design: The aim of this study was to identify an additional pathway in the NF1 tumorigenesis. We focused our work on Wnt s...