INTRODUCTION 363 KI.NETOPLAST MINICIRCLE DNA 365 Is There a Gene Product? 365 Sequence Organization in Different Species 365 Sequence Heterogeneity as a Diagnostic and Epidemiological Tool 368 Analysis of Conformational Bend in Minicircle DNA 370 Replication of Minicircle DNA 371 KINETOPLAST .MAXICIRCLE DNA 372 Mitochondrial Ribosomal R.VA genes 372 Mitochondrial Siruciural Genes and Open Readi...

The mitochondrial genome of the Peruvian scallop Argopecten purpuratus was determined. The length of the mitochondrial coding region is 15,608 bp. A typical bivalve mitochondrial composition was detected with 12 protein-coding genes, 2 ribosomal RNA genes and 21 transfer RNA genes, with the absence of the atp8 gene. Fifty percent of the protein-coding genes use typical ATG start codon, whereas ...

Many genes implicated in familial Parkinson disease (PD) code for proteins with mitochondrial function. Several of these genes, including PINK1 and PARK2, are involved in mitophagy, a mitochondrial quality control pathway. We describe a family with 3 members affected by autosomal dominant optic atrophy in which 2 affected members also developed PD. While the role of mitophagy-related genes in P...

Unlike in animals, the functional transfer of mitochondrial genes to the nucleus is an ongoing process in plants. All but one of the previously reported transfers in angiosperms involve ribosomal protein genes. Here we report frequent transfer of two respiratory genes, sdh3 and sdh4 (encoding subunits 3 and 4 of succinate dehydrogenase), and we also show that these genes are present and express...

Mitochondrial disorders, although heterogeneous, are traditionally described as conditions characterized by encephalomyopathy, hypotonia, and progressive postnatal organ failure. Here, we provide a systematic review of Linear Skin Defects with Multiple Congenital Anomalies (LSDMCA), rare, unconventional mitochondrial disorder which presents developmental disease; its main clinical features incl...

Complete mitochondrial genome of the acid-tolerant fungus Penicillium ShG4C, isolated from oxidized sediments of an abandoned polymetallic mine site, has been sequenced using high-throughput sequencing approach. The mitochondrial genome represents a circular DNA molecule with size of 26,725 bp. It encodes a usual set of mitochondrial genes, including 15 protein coding genes, large and small rib...