Interleukin-1beta is up-regulated in the presence of Helicobacter pylori infection. H. pylori infection was associated with E-cadherin methylation. In this study, we examined if IL-1beta could induce promoter methylation of E-cadherin in human gastric cancer cell lines TMK-1, MKN-74 and MKN-7. Cells were treated with IL-1beta (0.025, 0.1, 0.25, 1.0, 2.5 ng/mL) for 6, 12 and 24h. Methylation sta...

The ionized disc reflection model of Ross & Fabian is applied to a sample of five Seyfert 1 galaxies observed by BeppoSAX. Good fits were obtained for all the objects in the sample. NGC 4051 and Mkn 335 (usually classified as NLSy 1s) show evidence of a highly ionized accretion disc (ξ ∼ 350 erg cm s and ξ ∼ 800 erg cm s). While NGC 3783 seems to be a “pure Sy 1” characterized by a highly ioniz...

The intrinsic BL Lac spectra above few hundreds GeV can be very different from the observed ones due to the absorption effects by the diffuse Extragalactic Background Light (EBL), at present poorly known. With the recent results, there are now 4 sources with good spectral information: Mkn 421 (z=0.031), Mkn 501 (z=0.034), 1ES 1426+428 (z=0.129) and 1ES 1959+650 (z=0.047). Making simple assumpti...

Observations of the multi-TeV spectra of the nearby BL objects Mkn 421 and Mkn 501 exhibit the high energy cutoffs predicted to be the result of intergalactic annihilation interactions, primarily with infrared photons having a flux level as determined by various astronomical observations. After correction for this absorption effect, the derived intrinsic spectra of these multi-TeV sources can b...

The purpose of this study is to find out and examine the differences in development Notary Honorary Council (MKN) Supervisory (MPN) as well implementation guidance by Yogyakarta City Notary. This research normative with statutory conceptual approaches. results concluded that first, MKN MPN providing Notaries have similar mentoring authority differences, only provides task implementing Notaries....

The gluon condensation in the proton as a dynamical model is used to treat series of unsolved puzzles sub-TeV gamma ray spectra, they include broken power-law blazar's radiation, hardening confusion 1ES 1426+428, Mkn 501, and recently recorded spectra GRB 180720B 190114C. We find that above anomalous phenomena energy can be understood with simple power law based on QCD effect.