Anatomical and neurochemical results suggest that the cortico- and amygdalopetal cholinergic neurons of the nucleus basalis magnocellularis (NBM) may receive GABAergic inputs. The present experiments were undertaken to evaluate the possible influence of intra-NBM injections of the GABAA agonist, muscimol, on memory. In two experiments, rats were chronically implanted with guide cannulae placed ...

In this study, one-trial step-through task was applied to reveal the effect of prefrontal infralimbic cortex GABAA receptor agitating on passive avoidance memory consolidation in rats. Immediately after training (with shock), GABAA receptor agonist, muscimol (0.5 μg/0.25 μL) or saline (0.25 μL) was infused into the test animal's infralimbic cortex, then, the latencies of rats stepping through t...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...

Introduction: Ginger has shown anti-nociceptive effects. Here we investigated the possible involvement of GABAA receptors in anti-nociceptive effect of ginger using muscimol (GABAA agonist) and picrotoxin (GABAA antagonist) in rats that received ginger. The pain sensitivity was evaluated by formalin test. Methods: Thirty-five male Sprague-Dawley rats were randomly divided into 7 groups (n=5): s...

background: estradiol and progesterone as well as hippocampal gabaa receptors are believed to play a role in the modulation of pain. the aim of present study was to investigate the effect of intrahippocampal injections of gabaa receptor agonist (muscimol) and gabaa receptor antagonist (picrotoxin) on pain sensitivity during estrous cycle. methods: pain sensitivity was evaluated in rats by forma...

these experiments examined the effects of pre-test intra dorsal hippocampus (intra-ca1) administration of gabaa receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. male nmri mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received ip injections of either saline (10 ml/kg...

An important constraint on how hemodynamic neuroimaging signals such as fMRI can be interpreted in terms of the underlying evoked activity is an understanding of neurovascular coupling mechanisms that actually generate hemodynamic responses. The predominant view at present is that the hemodynamic response is most correlated with synaptic input and subsequent neural processing rather than spikin...

Whole-cell voltage-clamp recordings were made in thin transverse slices from neurons of the dorsomedial subdivision of the nucleus of the tractus solitarius (NTS) of the rat. Cells were exposed to either the ionotropic glutamate receptor agonist (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) or the GABAA receptor agonist muscimol via pressure ejection directed at the cell so...

Cervical dystonia (CD; spasmodic torticollis) can be evoked by inhibition of substantia nigra pars reticulata (SNpr) in the nonhuman primate (Burbaud et al., 1998; Dybdal et al., 2012). Suppression of GABAergic neurons that project from SNpr results in the disinhibition of the targets to which these neurons project. It therefore should be possible to prevent CD by inhibition of the appropriate ...