conclusions no interactivity is present in modulatory effects of gabaa receptors and elf-emfs on serum testosterone of male rats. patients and methods fifty adult male rats were randomly assigned into 10 groups. groups 2, 4, 6, 8, and 10 were exposed to elf-emf for 30 days 8hrs per day; while, the remaining groups (1, 3, 5, 7, and 9) were sham exposed animals. at the end of the experiment, anim...

BACKGROUND GABA can influence the steroidogenesis in peripheral and central nervoussystems. OBJECTIVES The present study investigates the interactive effect of GABAA receptors and extremely low frequency electromagnetic field on serum testosterone level of male rats. PATIENTS AND METHODS Fifty adult male rats were randomly assigned into 10 groups. Groups 2, 4, 6, 8, and 10 were exposed to E...

There is evidence that GABA plays a major role in sleep regulation. GABA(A) receptor agonists and different compounds interacting with the GABA(A) receptor complex, such as barbiturates and benzodiazepines, can interfere with the sleep/wake cycle. On the other hand, there is very little information about the possible role of GABA(B) receptors in sleep modulation. The nucleus basalis of Meynert ...

This research was undertaken with an aim to formulate dextromethorphan hydrobromide as extended release micropellets. The Preformulation studies were carried out on drug Dextromethorphane Hydrobromide and it shows that Drug has good flow property. Various ion exchange resins screened for complexation the ratio of drug: resin optimized along manufacturing process complexation. Drug-Resin complex...

The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed...

The antioxidant properties of galantamine hydrobromide ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide) were studied in vitro, using luminol-dependent chemiluminescence and spectrophotometry. It was found that this compound was a scavenger of reactive oxygen species (ROS). By comparing the antioxidant effects of galantamine ((...

the present work was performed to show the possible interaction of gab a, and gabab receptors in catalepsy. the following results were obtained: 1- muscimol (mus), a gabaa agonist, induced catalepsy. this effect was dose-dependent. baclofen (bac), a gabab agonist, had no effect in this respect. 2- catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (bic), a...

Eletriptan hydrobromide (1) is a selective serotonin (5-HT(1)) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC-MS. To control the formation of these impurities during the preparation of active pharmaceutical ingredients, the structure of the i...