نتایج جستجو برای: muscle pathology
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Introduction: According to EAU 2018 guidelines, TURBT is the gold standard method for diagnosis and treatment of non-muscle invasive bladder tumor. It has been reported that in 50% of cases no detrusor was found in the specimen. The aim of this study is to compare presence of detrusor in specimens taken by conventional and en-bloc method. Methods: From September 2017 to September 2018, 60 patie...
BACKGROUND Pompe disease, an inherited deficiency of lysosomal acid alpha-glucosidase (GAA), is a metabolic myopathy with heterogeneous clinical presentations. Late-onset Pompe disease (LOPD) is a debilitating progressive muscle disorder that can occur anytime from early childhood to late adulthood. Enzyme replacement therapy (ERT) with recombinant human GAA is currently available for Pompe pat...
Mitochondria are dynamic organelles that constantly undergo fusion and fission to maintain their normal functionality. Impairment of mitochondrial dynamics is implicated in various neurodegenerative disorders. Amyotrophic lateral sclerosis (ALS) is an adult-onset neuromuscular degenerative disorder characterized by motor neuron death and muscle atrophy. ALS onset and progression clearly involve...
background: organic nitrates relax all kinds of smooth muscle , not only vascular smooth muscle , a fact that has allowed the use of these drugs to treat many different aliments. objective.-the purpuse of this study was to examine prosepectively benefical effects , if any, of sublingual nitroglycerin on the pain of renal colic. design.- prospective , randomised , double blind, placebo- contoled...
با توجه به ناقص بودن گزارشات پاتولوژی تومورهای بدخیم و اهمیت کامل بودن این گزارشات در تعیین پروگنوز و درمان بیماران مبتلا به ضایعات بدخیم بررسی نحوه گزارش آسیب شناسی ضایعات بدخیم آزمایشگاه های پاتولوژی شهر کرمانشاه طی سالهای 79 -1375 مطرح گردید. هدف بررسی نحوه گزارش آسیب شناسی ضایعات بدخیم در شهر کرمانشاه طی سالهای 79 -1375 و مقایسه آن با استانداردهای موجود در کتاب surgical pathology ackerman...
microRNAs (miRNAs) are widespread regulators of gene expression, but little is known of their potential roles in congenital muscular dystrophy type 1A (MDC1A). MDC1A is a severe form of muscular dystrophy caused by mutations in the gene encoding laminin α2 chain. To gain insight into the pathophysiological roles of miRNAs associated with MDC1A pathology, laminin α2 chain-deficient mice were eva...
Mutations in the dystrophin gene give rise to Duchenne and Becker muscular dystrophies (DMD and BMD), in which both skeletal and cardiac muscles are affected, but also to X-linked dilated cardiomyopathy (XLDC), a condition characterised by exclusive cardiac involvement. XLDC patients with mutations at the 5' end of the gene typically have a cardiac specific severe transcriptional pathology, wit...
BACKGROUND IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (mdx) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is believed to contribute to the chronic inflammation and failure of muscle regeneration in DMD. The purpose of the current study was to examine the...
Three-dimensional optical coherence tomography (3D-OCT) is used to evaluate the structure and pathology of regenerating mouse skeletal muscle autografts for the first time. The death of myofibers with associated inflammation and subsequent new muscle formation in this graft model represents key features of necrosis and inflammation in the human disease Duchenne muscular dystrophy. We perform 3D...
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