BACKGROUND Nerve conduction block using high-intensity focused ultrasound (HIFU) has been conducted with nerves of mixed fibres in normal animal models. This study tested the feasibility and safety of HIFU for sensory nerve conduction block in diabetic neuropathic nerves to determine its potential for pain relief. METHODS Diabetes was induced in Sprague-Dawley rats using streptozotocin, and H...

Anoxia and KC1 have been used to inactivate peripheral nerves by depolarization conduction block. Investigation of the inactivation patterns in isolated sciatic nerves of healthy and alloxan-diabetic rats suggests that the paranodal gap substance of healthy nerve behaves as an effective periaxonal diffusion barrier. In diabetic nerve the permeability of this barrier is significantly increased. ...

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na(+), Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conducti...

Previous studies suggested that activity-dependent conduction block (CB) contributes to weakness in multifocal motor neuropathy (MMN). Obtaining more robust evidence for activity-dependent CB is important because it may be a novel target for treatment strategies. We performed nerve conduction studies in 22 nerve segments of 19 MMN patients, before and immediately after 60 seconds of maximal vol...

stricted peripheral nerves by implanted, multicontact nerve cuff electrodes and correlated with morphometric histology in selected cases. The physiological and histological responses in nerve to a range of constricting cuffs of standard sizes were readily graded. The initial response to any significant constriction was a transient, focal conduction slowing or block at the constriction, followed...

conclusions the study indicated advantages of this modified bier's block compared to the traditional one including ability to perform surgery on upper limb bones and considerable pain relief at surgical and tourniquet sites during the operation until one hour thereafter. results this study showed the presence of analgesia at surgical and tourniquet sites during the operation in 96% of patients,...

Electrophysiological properties were monitored in detail in chronically constricted peripheral nerves by implanted, multicontact nerve cuff electrodes and correlated with morphometric histology in selected cases. The physiological and histological responses in nerve to a range of constricting cuffs of standard sizes were readily graded. The initial response to any significant constriction was a...

Motor nerve conduction (MNC) from proximal and distal points of the median and ulnar nerve was examined in 14 patients receiving a total of 29 i.v. regional anaesthetics (IRA) with bupivacaine hydrochloride in doses ranging from 100 to 300 mg. Conduction was tested during and following vascular obstruction, until MNC returned to pre-IRA value. After 20 min of obstruction, MNC was unobtainable i...

Regional anesthesia (RA) is an interplay between the local anesthetic (LA) solution and neural structures, resulting in nerve conduction blockade. For that, it necessary to understand which hurdles LA has overcome components of nerves are involved. Background knowledge non-neural helps locate safest area for deposition. In addition, physiology process patterns block onset, involved fibers, regr...

background: incidence and predominant subtype  of guillain-barre syndrome (gbs) differs geographically. electrophysiology has an important  role in early diagnosis and  prediction  of prognosis. this study  is conducted to determine the frequent  subtype  of gbs in a large group of patients  in iran and compare  nerve conduction studies in axonal and demyelinating forms of gbs. methods:    we  ...