introduction abnormal neural impulses in the nervous system may lead to various diseases and disabilities. high frequency alternating currents (hfac) has been used to block the propagation of such impulses and improve the symptoms or disabilities. the technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...

Conduction block was detected in patients with neuropathy by measuring a decrease in the size of the compound muscle action potential of more than 20% on proximal versus distal stimulation of the peroneal, median or ulnar nerve in the absence of excess temporal dispersion of the potential. The teased fibre analyses of nerve biopsies from four patients with "definite" and six patients with "prob...

Acute experimental allergic neuritis was induced in Lewis rats by inoculation with bovine intradural root myelin and adjuvants. In terminal experiments, sensory conduction was assessed in rats with hindlimb ataxia and weakness by stimulating the exposed sciatic nerve and recording directly from the exposed L-4 spinal nerve, dorsal root ganglion, dorsal root, and dorsal root entry zone. Focal co...

introduction: high frequency alternating currents is a safe, reversible and selective method for nerve conduction block that has been under study during the last decade as a treatment for the diseases involving abnormal neural impulses. however, reducing the stimulus amplitude, and the undesired onset response, as well as optimizing the stimulus parameters for more effective block is still unde...

Background: This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. Methods: In 13 cats, conduction block of pudendal nerves by cooling (5–30 °C) or heating (42–54 °C) a small segment of the nerve was monitored by the urethral striated muscle contractions and incre...

Background: This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. Methods: In 13 cats, conduction block of pudendal nerves by cooling (5–30 °C) or heating (42–54 °C) a small segment of the nerve was monitored by the urethral striated muscle contractions and incre...

Guillain-Barré syndrome is divided into two major subtypes, acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. The characteristic electrophysiological features of acute motor axonal neuropathy are reduced amplitude or absence of distal compound muscle action potentials indicating axonal degeneration. In contrast, autopsy study results show early nodal changes in ...

Introduction Abnormal neural impulses in the nervous system may lead to various diseases and disabilities. High frequency alternating currents (HFAC) has been used to block the propagation of such impulses and improve the symptoms or disabilities. The technique is safe, reversible, and relatively selective, and its reliability, the optimum stimulation parameters, and elimination of the onset re...

Serial electrophysiological studies were performed in a case of 'tourniquet paralysis' of the upper limb after the application of an Esmarch bandage above the elbow. Three months after onset of paralysis, nerve conduction was reduced to a quarter of normal between elbow and and axilla along the few fibres still conducting through the lesion, but was normal distal to the block. Seven months afte...

A reversible nerve-blocking spin label, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) was used to study the nature of anesthetic-binding sites in nerve membranes as a function of pressure. The nerve-blocking effect of TEMPO is enhanced under pressure. At atmospheric pressure, TEMPO blocks nerve conduction by solubilizing in the apolar region of the nerve membrane. However, the nerve-conduction-b...