THE INTERACTION Of antibiotics and neuromuscular blocking agents has been well documented. Neomycin, a.-~ streptomycin, 3 kanamycin, 3 gentamicin, 4'~ bacitraein, G polymyxin B ~ and colymicin ~ have been shown to potentiate the neuromuscular blockade of d-tubocurarine. The combined action of the muscle relaxant and the antibiotic is often resistant to reversal by both calcium '2,~3,~4 and neos...

Neuromuscular blockade is a pharmacological adjunct for anesthesia and for surgical interventions. Neuromuscular blockers can facilitate ease of instrumentation and reduce complications associated with intubation. An undesirable sequela of these agents is residual neuromuscular blockade. Residual neuromuscular blockade is linked to aspiration, diminished response to hypoxia, and obstruction of ...

A 49-year-old male with amyotrophic lateral sclerosis (ALS) was scheduled for gastrectomy. Anesthetic management was performed under general anesthesia with sevoflurane and epidural anesthesia with lidocaine. He showed increased response to vecuronium under monitoring of neuromuscular block. But he responded favorably to anticholineesterase. He had little pain and showed no progress in neurolog...

We present a case where rocuronium 80 mg (3 x ED95) was used in a rapid sequence induction in a 80-kg pregnant patient with an open eye injury. The patient was also receiving magnesium 2 g h-1 i.v. for preterm labour. The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be approximately 53 min; with infusion of magnesium, the duration of neuromuscular bl...

Editor’s key points † The influence of electromyographic (EMG) activity neuromuscular block (NMB) on bispectral index (BIS) is controversial. † BIS was measured before and after reversal of NMB with sugammadex or neostigmine. † BIS increased after both agents only in patients with EMG activity. † This effect should be taken into account when using BIS. Background. Sugammadex is a modified g-cyc...

iontophoresis of epinephrine for assessment of neuromuscular junction response is a new technique that can improve diagnose of neuromuscular dysfunction. the purpose of this study was to investigate the effects of iontophoresis of epinephrine on neuromuscular junction response. iontophoresis of epinephrine solution (1mg/ml), sodium chloride, calcium gluconate, epinephrine with sodium chloride a...

Editor—We read with great interest the article by Nitahara and colleagues showing concentration-dependent inhibitory effects of sevoflurane on neuromuscular transmission in myasthenia gravis (MG) patients which was more prominent in patients with a pre-anaesthetic T4/T1,0.9. In their study, T4/T1 returned to baseline value in all patients at the end of anaesthesia. The importance of monitoring ...