Hypothermia has been demonstrated to be an effective neuroprotective strategy in a number of models of ischaemic and excitotoxic neurodegeneration in vitro and in vivo. Reduced glutamate release and free radical production have been postulated as potential mechanisms underlying this effect but no definitive mechanism has yet been reported. In the current study, we have used oxygen-glucose depri...

Tacrolimus (FK506) and cyclosporin A (CsA) are immunosuppressants that have well-known neuroprotective actions. However, the drugs also have numerous negative neurological side effects observed in clinical practice. The problem of the long-term consequences of the immunosuppressive treatment has never been explored experimentally. Therefore, we focused on the FK506 and CsA influence on the deve...

The present work was carried out to elucidate the role of NSAIDs, PPARg agonist and HMG CoA inhibitor on cholesterol and lipopolysaccharide (LPS) induced neurodegeneration. The cerebellar, neuronal cells were exposed to cholesterol (10 and 50 microg/ml), LPS (1 ng/ml) or both. Neuroprotective effect of ibuprofen, rofecoxib, simvastatin and pioglitazone was assessed by measuring the neuronal los...