CONTEXT High-density lipoprotein (HDL) cholesterol is an inverse predictor of coronary atherosclerotic disease. Preliminary data have suggested that HDL infusions can induce atherosclerosis regression. OBJECTIVE To investigate the effects of reconstituted HDL on plaque burden as assessed by intravascular ultrasound (IVUS). DESIGN AND SETTING A randomized placebo-controlled trial was conduct...

The aim of the present work was to determine whether the administration of melatonin or L­-tryptophan (a precursor of melatonin) affects the immune responses and performance of broilers during induced exposure to aflatoxins in feed. The study was conducted from 0-6 weeks comprising six dietary treatments in triplicate with10 chickens in each replicate. The diets were formulated to supply 23% cr...

A total of 292 sows, at three experimental stations (Auburn, Texas A&M, Texas Tech), was used to determine the effects of depriving sows of feed and(or) water before weaning on reproductive performance. The four treatments were arranged as a 2 X 2 factorial to evaluate two periods of feed deprivation (0 and 48 h) and two periods of water deprivation (0 and 24 h) before weaning. Sows were allowe...

Notch signaling is an important regulator of stem cell differentiation. All canonical Notch signaling is transmitted through the DNA-binding protein CSL, and hyperactivated Notch signaling is associated with tumor development; thus it may be anticipated that CSL deficiency should reduce tumor growth. In contrast, we report that genetic removal of CSL in breast tumor cells caused accelerated gro...

The aim of this study was to use PARACHEK Johne's Absorbed EIA-CSL, gamma interferon test IFN BOVIGAM-CSL , Mycobacterial Growth Indicator Tube MGIT, BACTEC 960 BECTON-DICKINSON, PCR with IS900 probe, to diagnose paratuberculosis in sheep from the Argentine North East (ANE) and compare the results with those of the comparative skin testing using bovine and avian PPD (B-PPD and A-PPD), agar gel ...

Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. RTA, the replication and transcription activator of KSHV, can either directly bind to DNA or use cellular DNA binding factors including CBF1/CSL as DNA adaptors. In addition, the viral factors LANA1 and vIRF4 are known to bind to CB...

Notch signaling mediates communication between cells and is essential for proper embryonic patterning and development. CSL is a DNA binding transcription factor that regulates transcription of Notch target genes by interacting with coregulators. Transcriptional activation requires the displacement of corepressors from CSL by the intracellular portion of the receptor Notch (NotchIC) and the recr...