This study aimed to verify the reliability of the 7 tissue differentially methylated regions used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based approach of fetal DNA in maternal blood to diagnosis of fetal trisomy 21. Forty pregnant women with high risk pregnancy who were referred after first or second trimester screeni...

Recent advances in genomic sequencing and bioinformatics have led to the development of noninvasive detection methods with detection rates approaching those obtained with amniocentesis and chorionic villus sampling (CVS) [1, 2]. Recently, a novel prenatal testing method has become available. This method, known as noninvasive prenatal testing (NIPT), is a molecular approach for assessing fetal a...

Abstract— In this paper we report on the separation of maternal and fetal heartbeats from electrocardiogram (ECG) recordings based on a sparse generative signal model. The proposed algorithm uses Bayesian learning strategies to both learn the characteristic PQRST complexes and then infer their time location. Reconstruction of the signal based on each of the learned PQRST complexes leads to a se...

Fetal electrocardiogram (FECG) morphology plays an essential role in the early diagnosis of fetal health conditions. However, it is intractable to extract clean FECG signals, which are usually contaminated by maternal ECG (MECG) and various noises. To signals from non-invasive abdominal records, a high-performance high-efficient two-stage slow-fast long short-term memory (SFLSTM) based architec...